Results 101 to 110 of about 430,420 (317)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

An effective DE algorithm for hybrid flow shop load balancing scheduling problem

, 2015
In this paper, an improved DE algorithm called double population self-adaptive differential evolution (DPSADE) algorithm is used to solve the hybrid flow shop load balancing scheduling problem (HFS-LBSP) which combines a novel double population ...
Han ZH(韩忠华), Lin S(林硕), Dong XT(董晓婷)   +2 more
core  

Reducing voltage fluctuations using DSTATCOMs and reactive power of PV inverters in a medium voltage distribution system

The Journal of Engineering, 2019
This paper proposes local reactive power control to mitigate the voltage fluctuation in medium-voltage systems using DSTATCOMs and photovoltaic (PV) inverters.
Duong Quoc Hung, Yateendra Mishra, Geoffrey Walker   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Three dimensional flow structures in journal bearings

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
Stucke, P, 2nd Micro and Nano Flows Conference (MNF2009), Nobis, M, Schmidt, M   +3 more
core  

Security constrained reactive power dispatch in electrical power systems [PDF]

, 1990
With the increased loading and exploitation of the power transmission system and also due to improved optimised operation, the problem of voltage stability and voltage collapse attracts more and more attention .
Chebbo, Ahmad Mustapha
core  

Impact of Electric Vehicles Charging on Urban Residential Power Distribution Networks

Energies
Achieving transportation decarbonization and reducing carbon emissions are global initiatives that have attracted a lot of effort. The use of electric vehicles (EVs) has experienced a significant increase lately, which will have a considerable impact on ...
Mohamed El-Hendawi, Zhanle Wang, Raman Paranjape, James Fick, Shea Pederson, Darcy Kozoriz   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Modelling of phosphorus inputs to rivers from diffuse and point sources.

, 2008
The difference in timing of point and diffuse phosphorus (P) delivery to a river produces clear differences in the P concentration – flow relationship.
Bowes, M., Jarvie, Helen P., Smith, Jim, Bowes, Michael J., Smith, Jim T., Neal, Colin, Neal, C., Jarvie, H.   +7 more
core   +1 more source