Results 161 to 170 of about 430,420 (317)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The acute respiratory response to blood-flow restriction resistance exercise in healthy adults: A randomized crossover trial. [PDF]

Physiol Rep
Kuhn M, Kohlbrenner D, Kläy A, Kohler M, Gheza A, Mayer LC, Radtke T, Haile SR, Baur DM, Sievi NA, Clarenbach CF.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Load flow method using genetic algorithm

, 2003
Genetic algorithms (GAs) are search methods based on the natural selection and natural genetics, while power flow studies, commonly known as load flow, form an important part of power system analysis.
Mustafa, M. W., Lo, Kueiming Lun, Lok, C. W., Zin, A. A. M.   +3 more
core  

Study on the adaptability of multilayer subway network under sudden large passenger flow disturbances. [PDF]

PLoS One
Lin NN, Yuan HW, Huang HT, Liu ZG.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Load flow feasibility under extreme contingencies

, 2007
This thesis examines the problem of load flow feasibility, in other words, the conditions under which a power network characterized by the load flow equations has a steady-state solution.
Khosravi-Dehkordi, Iman.
core  

Defining a diaphragm-focused and patient-acceptable inspiratory muscle training (IMT) load in difficult to wean, mechanically ventilated patients: a protocol for a prospective, mixed methods study. [PDF]

BMJ Open Respir Res
Jenkins TO, Polkey MI, McWilliams D, Kilbride C, MacBean V.   +4 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Hybrid Weld-Bonded Joints: A Critical Comparative Review of Welding Processes, Adhesive Interaction and Joint Performance. [PDF]

Materials (Basel)
Krawczuk A.
europepmc   +1 more source