Results 71 to 80 of about 4,629 (213)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Load Frequency Control of an Isolated Micro Grid Using Fuzzy Adaptive Model Predictive Control

open access: yesIEEE Access, 2017
This paper presents a fuzzy adaptive model predictive approach for load frequency control of an isolated micro grid. A generalized state space model of a typical isolated micro grid having controllable and uncontrollable generating power sources is ...
S. Kayalvizhi, D. M. Vinod Kumar
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

THE MODELLING OF ELECTRIC POWER SYSTEMS ON THE STATE SPACE AND CONTROLLING OF OPTIMAL LQR LOAD FREQUENCY

open access: yesElectrica, 2009
The modelling of electric power systems on the state space and an optimal control system known as Linear Quadratic Regulator (LQR) for designing the load frequency control system are realized in this paper. In order to obtain high quality electric energy
ADNAN KAKİLLİ   +2 more
doaj   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Determinación de diapasones de potencia necesarios para el control de frecuencia en el sistema eléctrico cubano; Determination of Necessary Ranges of Power for the Frecuency Control in Cuban Electric System

open access: yesRevista Científica de Ingeniería Energética, 2011
Basado en un análisis estadístico de una base de datos en tiempo real se propone un procedimiento paradeterminar los diapasones de potencia activa necesarios para desarrollar un efectivo control de la frecuencia. A generalized approach
Antoino A Martínez García   +3 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Takagi-Sugeno fuzzy gain controller for Vehicle-to-Grid (V2G) load frequency control

open access: yesSystems and Soft Computing
Load Frequency Control (LFC) has gained more importance with the introduction of deregulated Renewable Energy Sources (RES) connectivity with the grid.
Marayati Marsadek   +4 more
doaj   +1 more source

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