Results 41 to 50 of about 120,732 (263)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimization and Improvement of Frequency Modulation Auxiliary Service Control System for the 700 MW Unit

open access: yes南方能源建设, 2021
[Introduction] The DCS system of two 700 MW units adopting "constant-sliding-constant" variable pressure operation mode in Zhuhai Power Plant adopts DIASYS Netmation distributed control system, which is provided by Mitsubishi company of Japan. At present,
LI Qiang
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Extension of Quasi-Load Insensitive Generalized Class-E Doherty Operation with Complex Load Trajectories

open access: yesChips
This paper extends the quasi-load insensitive (QLI) Class-E Doherty power amplifier (PA) design methodology to address Doherty PA combiners with complex load impedance trajectories.
Mehdi Otmani   +5 more
doaj   +1 more source

Frequency Modulation Control of Hydraulic Wind Turbines Based on Ocean Used Wind Turbines and Energy Storage

open access: yesEnergies, 2022
Based on the energy storage type of hydraulic wind turbines (HWTs) and in view of the unit frequency drop problem under high wind power proportion conditions, this paper proposes a method of primary frequency control under maximum power point tracking ...
Lijuan Chen   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Analytical Design Space of Power Amplifiers Including the Class-A/B/J Continuum for Dynamic Load Modulation

open access: yesIEEE Access, 2019
In this paper, an analytical design space of power amplifiers (PAs) including the Class-A/B/J continuum for dynamic load modulation (DLM) at the current generator plane (CGP) is proposed based on the theory of load modulated (LM) continuous Class-B/J PAs.
Xuekun Du   +6 more
doaj   +1 more source

A PWM/PFM Dual-Mode DC-DC Buck Converter with Load-Dependent Efficiency-Controllable Scheme for Multi-Purpose IoT Applications

open access: yesEnergies, 2021
This paper presents a dual-mode DC-DC buck converter including a load-dependent, efficiency-controllable scheme to support multi-purpose IoT applications. For light-load applications, a selectable adaptive on-time pulse frequency modulation (PFM) control
Myeong Woo Kim, Jae Joon Kim
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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