Results 181 to 190 of about 1,619,191 (308)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Assessing the effect of electronic health information exchange on the completeness and validity of data for measuring viral load testing turnaround time in Nigeria. [PDF]

Int J Med Inform, 2023
Aniekwe C, Cuffe K, Audu I, Nalda N, Ibezim B, Nnakwe M, Anazodo T, Dada M, Rottinghaus Romano E, Okoye M, Martin M, Shrivastava R.   +11 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Impact of point-of-care maternal viral load testing at delivery on vertical HIV transmission risk assessment and neonatal prophylaxis: a cluster randomized trial. [PDF]

J Int AIDS Soc
Lwilla AF, Elsbernd K, Boniface S, Edom R, Mahumane A, Meggi B, Buck WC, Lequechane J, Pereira K, Chiwerengo N, Chale F, Mudenyanga C, Mutsaka D, Mueller M, Ntinginya NE, Taveira N, Hoelscher M, Jani I, Kroidl A, Sabi I, and the LIFE Study Consortium.   +20 more
europepmc   +1 more source

Point-of-Care Viral Load Testing to Manage HIV Viremia During the Rollout of Dolutegravir-Based ART in South Africa: A Randomized Feasibility Study (POwER). [PDF]

J Acquir Immune Defic Syndr, 2023
Dorward J, Sookrajh Y, Lessells R, Bulo E, Naidoo J, Naidoo K, Bodley N, Khanyile M, Van Vuuren CJ, Moodley P, Samsunder N, Lewis L, Drain PK, Hayward G, Butler CC, Garrett N.   +15 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Improving viral load testing coverage among orphan and vulnerable children in Jinka Town, South Ethiopia: a quality improvement project implemented by the USAID FFHPCT activity team. [PDF]

BMJ Open Qual
Dawud A, Tesfaw M, Gebrasilase T, Asefa A, Abota A, Ligaba F, Million A, Yosef Y, Tsegaye K, Markos M.   +9 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Barriers to effective sample management in viral load testing in Machakos County, Kenya: a convergent parallel mixed-method study. [PDF]

Pan Afr Med J
Kathinzi CM, Njenga PK, Mutai JK.
europepmc   +1 more source

Optimising courier specimen collection time improves patient access to HIV viral load testing in South Africa. [PDF]

Afr J Lab Med, 2022
Girdwood SJ, Crompton T, Cassim N, Olsen F, Sejake P, Diallo K, Berrie L, Chimhamhiwa D, Stevens W, Stevens W, Nichols B.   +10 more
europepmc   +1 more source