Results 161 to 170 of about 1,619,191 (308)

HIV Viral Load Testing in the South African Public Health Setting in the Context of Evolving ART Guidelines and Advances in Technology, 2013-2022. [PDF]

Diagnostics (Basel), 2023
Hans L, Cassim N, Sarang S, Hardie D, Ndlovu S, Venter WDF, Da Silva P, Stevens W.   +7 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Correction: Hodgkin lymphoma: the role of EBV plasma viral load testing in an HIV-endemic setting. [PDF]

Clin Exp Med
Opie J, Mohamed Z, Chetty D, Bailey J, Brown K, Verburgh E, Hardie D.   +6 more
europepmc   +1 more source

Progress in scale up of HIV viral load testing in select sub-Saharan African countries 2016-2018. [PDF]

PLoS One, 2023
Fonjungo PN, Lecher S, Zeh C, Rottinghaus E, Chun H, Adje-Toure C, Lloyd S, Mwangi JW, Mwasekaga M, Eshete YM, Pati R, Mots'oane T, Mitruka K, Beukes A, Mwangi C, Bowen N, Hamunime N, Beard RS, Kabuje A, Nabadda S, Auld AF, Balachandra S, Zungu I, Kandulu J, Alemnji G, Ehui E, Alexander H, Ellenberger D.   +27 more
europepmc   +1 more source

Philosophy on loading tests

, 1956
The authors review the criteria for loading tests for buildings and structural elements contained in building codes and find a lack of uniformity. Specifications of six major codes are presented in table form. Factors to be considered in formulating loading test specifications and in assessing structural adequacy are presented, using a philosophy that ...
Dorey, D. B., Schriever, W. R.
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Near point-of-care HIV viral load testing: Cascade after high viral load in suburban Yangon, Myanmar. [PDF]

PLoS One, 2023
Tun NN, Smithuis F, Tun NL, Min M, Hlaing MMM, Olmen JV, Lynen L, Gils T.   +7 more
europepmc   +1 more source

Results of the Round Robin on opening-load measurement conducted by ASTM Task Group E24.04.04 on Crack Closure Measurement and Analysis [PDF]

An experimental Round Robin on the measurement of the opening load in fatigue crack growth tests was conducted on Crack Closure Measurement and Analysis.
Phillips, Edward P.
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Hepatitis C missed diagnostic opportunities: The role of reflex viral load testing in the era of direct acting antivirals, a descriptive South African study from 2017 to 2021. [PDF]

S Afr J Infect Dis
Mthiyane H, Mashishi B, Patjane MA, Honwana N, Prabdial-Sing N, Hans L, Mbenenge N, Reddy B, Bangalee A, Treurnicht FK.   +9 more
europepmc   +1 more source