Results 141 to 150 of about 1,619,191 (308)

Point-of-care HIV viral load testing in a community antiretroviral therapy delivery programme: A randomised controlled trial (PHILA). [PDF]

PLOS Glob Public Health
Dorward J, Tlhaku K, Sookrajh Y, Munatsi P, Naidoo J, Tselana E, Maphumulo A, Mbambo N, Mhlongo-Gumbi T, Brown JA, Lewis L, Moodley P, Samsunder N, Drain PK, Butler CC, Hayward G, Garrett N.   +16 more
europepmc   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A philosophy on loading tests

, 1954
The purpose and scope of structural loading tests is reviewed and contrasted against the specifications for loading tests contained in present building codes, which are summarized in a table. The great diversity of these specifications points to a lack of basic principle.
Dorey, D. B., Schriever, W. R.
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Implementation of pooled testing to increase access to routine viral load monitoring for people living with HIV on antiretroviral therapy

Scientific Reports
For the 30 million people living with HIV on antiretroviral therapy, routine viral load testing is recommended to monitor treatment effectiveness. However, only an estimated 77% of eligible people accessed viral load testing in 2022, due to barriers ...
Gladys E. Fosah Tayong, Comfort Vuchas, Ngha Ndze Mbuh, Ubaida N. Suiteng, Cyrille Mbuli, Kingsley Che Soh, Albert Franck Zeh Meka, Serge C. Billong, Rina Djubgang, Gloria Ashuntantang, Vera Kum, Joseph Fokam, Moses Samje, Melissa Sander   +13 more
doaj   +1 more source

Analysis and testing of aeroelastic model stability augmentation systems [PDF]

Testing and evaluation of a stability augmentation system for aircraft flight control were performed. The flutter suppression system and synthesis conducted on a scale model of a supersonic wing for a transport aircraft are discussed.
Patel, S. M., Sevart, F. D.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

An inventory of aeronautical ground research facilities. Volume 3: Structural [PDF]

An inventory of test facilities for conducting acceleration, environmental, impact, structural shock, load, heat, vibration, and noise tests is presented.
Brown, K. R., Hardin, R. D., Heckart, M. V., Pirrello, C. J.   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source