Results 151 to 160 of about 1,619,191 (308)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Design and Implementation of Wireless Communication Function for APU Output-load Testing Device

机车电传动, 2014
In order to testing CRH2 EMUs output-load of APU, APU output-load testing device was developed. Design principle and implementation method of testing device’s wireless communication unit were introduced mainly. Through wireless communication unit, output-
TIAN Peng, QIU Wenjie
doaj  

An experimental investigation of retro-reinforced clay brick arches

, 2010
This paper describes the laboratory testing of eight 2.95m span segmental profile clay brick arches. Seven of the arches were strengthened with longitudinal intrados (soffit) reinforcement; the eighth was left unreinforced as an experimental control ...
Ashour, AF, Chen, Y, Garrity, SW
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Design, fabrication, test qualification and price analysis of a third generation solar cell module [PDF]

The design, fabrication, test, and qualification of a third generation intermediate load solar cell module are presented. A technical discussion of the detailed module design, preliminary design review, design modifications, and environmental testing are

core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Viral load testing coverage and suppression rate among children and adolescents on ART in Sierra Leone. [PDF]

Public Health Action
Kanu F, Lansana F, Mustapha M, Tabor EK, Thekkur P, Kamara IF, Fofanah BD, Kanu JS, Sesay N, Turay IS, Koroma JA, Lahai WK, Falama AM, Sesay MA, Lakoh S.   +14 more
europepmc   +1 more source

"It Soothes Your Heart": A Multimethod Study Exploring Acceptability of Point-of-Care Viral Load Testing among Ugandan Pregnant and Postpartum Women Living with HIV. [PDF]

Diagnostics (Basel), 2023
Nakyanzi A, Naddunga F, Bulterys MA, Mujugira A, Wyatt MA, Kamusiime B, Nalumansi A, Kasiita V, Peacock S, Celum CL, Ware NC.   +10 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Uptake and Timing of Viral Load Testing and Frequency of Viraemic Episodes During Pregnancy in South Africa. [PDF]

HIV AIDS (Auckl)
Jinga N, Technau KG, Clouse K, Ngcobo NB, Nattey C, Hwang C, Grimsrud A, Wise A, Van Dongen N, Ferreira T, Mudau M, Maskew M.   +11 more
europepmc   +1 more source