Results 91 to 100 of about 1,221,623 (254)

Investigating Ageing Effects on Bored Pile Shaft Resistance in Cohesionless Soil Through Field Testing

Geotechnics
This study investigates the influence of time (ageing) on the uplift capacity of bored piles in cohesionless silty sand through a full-scale field testing programme. Four reinforced concrete piles, two shorter (16 m) and two longer (21 m), were installed
Omar Hamza, Abdulhakim Mawas
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Superior Obstacle Avoidance Capabilities of Personal Mobility Vehicles (PMVs) Equipped with an Active Inward Tilting Mechanism

J
In recent years, novel Personal Mobility Vehicles (PMVs) with a narrow width and an inward tilting mechanism, similar to motorcycles (MCs), have been proposed to prevent overturning during turns.
Tetsunori Haraguchi, Tetsuya Kaneko, Ichiro Kageyama   +2 more
doaj   +1 more source

A LQR-Based Controller with Estimation of Road Bank for Improving Vehicle Lateral and Rollover Stability via Active Suspension

Sensors, 2017
In this article, a Linear Quadratic Regulator (LQR) lateral stability and rollover controller has been developed including as the main novelty taking into account the road bank angle and using exclusively active suspension for both lateral stability and ...
Andres Riofrio, Susana Sanz, Maria Jesus L. Boada, Beatriz L. Boada   +3 more
doaj   +1 more source

Fracture model with variable range of interaction

, 2002
We introduce a fiber bundle model where the interaction among fibers is modeled by an adjustable stress-transfer function which can interpolate between the two limiting cases of load redistribution, the global and the local load sharing schemes.
A. Garcimartin, A. Guarino, A. Hansen, A. Petri, B. Kahng, B.D. Coleman, B.D. Coleman, B.Q. Wu, B.Q. Wu, C. Baxenvanakis, C. Maes, C. Moukarzel, D. Sornette, D. Sornette, D.G. Harlow, D.G. Harlow, E. Brézin, F. Kun, Ferenc Kun, H.E. Daniels, Hans J. Herrmann, I.J. Beyerlein, I.J. Beyerlein, J. Sak, M. Ibnabdeljalil, M. Ibnabdeljalil, M. Kloster, M. Sahimi, M. Vázquez-Prada, P.C. Hemmer, R.L. Smith, Raul Cruz Hidalgo, S. Mahesh, S. Zapperi, S.L. Phoenix, S.L. Phoenix, W.A. Curtin, W.I. Newman, W.I. Newman, W.I. Newman, Y. Moreno, Yamir Moreno   +41 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Step change mechanism of static mechanical response of coal-rock in stope under structural transient excitation

Meitan xuebao
Revealing the occurrence mechanism of coal-rock mechanics response in the stope is theoretical basis for the prevention and control of coal-rock disasters. By adopting a combination of field measurements, simulation experiments, and theoretical analysis,
Shenghu LUO, Chengyang TIAN, Zhuangzhuang YAN, Yongping WU, Panshi XIE, Gang HAN, Tong WANG, Mingming SUN, Hongwei WANG, Xicai GAO, Ding LANG   +10 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Numerical Insights into Tunnel Excavation Effects on Pile-Supported Embankment in Soft Clay: A Comparison Between Consolidated and Unconsolidated Conditions

Buildings
This study examines the influence of adjacent tunnel excavation on pile-supported embankment in soft clay under both unconsolidated and long-term consolidated conditions.
Mukhtiar Ali Soomro, Shaokai Xiong
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source