Results 91 to 100 of about 1,221,101 (305)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A system-level mathematical model for evaluation of power train performance of load-leveled electric-vehicles [PDF]

The power train performance of load leveled electric vehicles can be compared with that of nonload leveled systems by use of a simple mathematical model. This method of measurement involves a number of parameters including the degree of load leveling and
Leising, C. J., Purohit, G. P.
core   +1 more source

Transient response analysis for DC-DC boost converter [PDF]

, 2014
DC-DC Boost Converter and Hybrid Posicast Controller is developed and simulated using MATLAB Simulink software. DC-DC Boost converter has a very high overshoot and a very high settling time which produce oscillated output response.
Libau, Charles Muling
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Investigating Ageing Effects on Bored Pile Shaft Resistance in Cohesionless Soil Through Field Testing

Geotechnics
This study investigates the influence of time (ageing) on the uplift capacity of bored piles in cohesionless silty sand through a full-scale field testing programme. Four reinforced concrete piles, two shorter (16 m) and two longer (21 m), were installed
Omar Hamza, Abdulhakim Mawas
doaj   +1 more source

A LQR-Based Controller with Estimation of Road Bank for Improving Vehicle Lateral and Rollover Stability via Active Suspension

Sensors, 2017
In this article, a Linear Quadratic Regulator (LQR) lateral stability and rollover controller has been developed including as the main novelty taking into account the road bank angle and using exclusively active suspension for both lateral stability and ...
Andres Riofrio, Susana Sanz, Maria Jesus L. Boada, Beatriz L. Boada   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Superior Obstacle Avoidance Capabilities of Personal Mobility Vehicles (PMVs) Equipped with an Active Inward Tilting Mechanism

J
In recent years, novel Personal Mobility Vehicles (PMVs) with a narrow width and an inward tilting mechanism, similar to motorcycles (MCs), have been proposed to prevent overturning during turns.
Tetsunori Haraguchi, Tetsuya Kaneko, Ichiro Kageyama   +2 more
doaj   +1 more source

Dowel Bar Optimization: Phases I and II, October 2001 [PDF]

, 2001
America’s roadways are in serious need of repair. According to the American Society of Civil Engineers (ASCE), one-third of the nation’s roads are in poor or mediocre condition (1).

core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source