Results 101 to 110 of about 1,221,101 (305)

Step change mechanism of static mechanical response of coal-rock in stope under structural transient excitation

Meitan xuebao
Revealing the occurrence mechanism of coal-rock mechanics response in the stope is theoretical basis for the prevention and control of coal-rock disasters. By adopting a combination of field measurements, simulation experiments, and theoretical analysis,
Shenghu LUO, Chengyang TIAN, Zhuangzhuang YAN, Yongping WU, Panshi XIE, Gang HAN, Tong WANG, Mingming SUN, Hongwei WANG, Xicai GAO, Ding LANG   +10 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Numerical Insights into Tunnel Excavation Effects on Pile-Supported Embankment in Soft Clay: A Comparison Between Consolidated and Unconsolidated Conditions

Buildings
This study examines the influence of adjacent tunnel excavation on pile-supported embankment in soft clay under both unconsolidated and long-term consolidated conditions.
Mukhtiar Ali Soomro, Shaokai Xiong
doaj   +1 more source

Tri-critical behavior in rupture induced by disorder

, 1996
We discover a qualitatively new behavior for systems where the load transfer has limiting stress amplification as in real fiber composites. We find that the disorder is a relevant field leading to tri--criticality, separating a first-order regime where ...
A. A. Pollock, A. Aharony, A. G. Tumarkin, A. Hansen, A. N. Berker, A. Petri, A. Sornette, B. Voight, C. J. Allègre, C. Vanneste, D. Sornette, D. Sornette, D. Sornette, Didier Sornette, H. E. Daniels, I. G. Main, J. M. Normand, J. Schmittbuhl, J. V. Andersen, J.-C. Anifrani, Jørgen Vitting Andersen, K.-t. Leung, Kwan-tai Leung, L. Lamaignère, M. Berry, M. W. Suh, P. Diodati, P. K. Sen, R. F. Smalley, S. Alexander, S. J. Zhou, W. Newman   +31 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Trajectory Tracking and Driving Torque Distribution Strategy for Four-Steering-Wheel Heavy-Duty Automated Guided Vehicles

Machines
A four-steering-wheel heavy-duty Automated Guided Vehicle (AGV) is prone to lateral instability and wheel slippage during acceleration, climbing, and small-radius turns.
Xia Li, Xiaojie Chen, Shengzhan Chen, Benxue Liu, Chengming Wang   +4 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Performance-based optimization of structures: theory and applications [PDF]

, 2005
Performance-based Optimization of Structures introduces a method to bridge the gap between optimization theory and its practical applications to structural engineering.
Liang, Qing Quan
core  

Metamaterial-Enhanced Coupling between Magnetic Dipoles for Efficient Wireless Power Transfer

, 2011
Non-radiative coupling between conductive coils is a candidate mechanism for wireless energy transfer applications. In this paper, we propose a power relay system based on a near-field metamaterial superlens, and present a thorough theoretical analysis ...
Smith, David R., Urzhumov, Yaroslav
core   +1 more source