Results 101 to 110 of about 1,221,623 (254)

Device for measuring hole elongation in a bolted joint [PDF]

, 1987
A device to determine the operable failure mode of mechanically fastened lightweight composite joints by measuring the hole elongation of a bolted joint is disclosed.
Wichorek, Gregory R.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Trajectory Tracking and Driving Torque Distribution Strategy for Four-Steering-Wheel Heavy-Duty Automated Guided Vehicles

Machines
A four-steering-wheel heavy-duty Automated Guided Vehicle (AGV) is prone to lateral instability and wheel slippage during acceleration, climbing, and small-radius turns.
Xia Li, Xiaojie Chen, Shengzhan Chen, Benxue Liu, Chengming Wang   +4 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transient response analysis for DC-DC boost converter [PDF]

, 2014
DC-DC Boost Converter and Hybrid Posicast Controller is developed and simulated using MATLAB Simulink software. DC-DC Boost converter has a very high overshoot and a very high settling time which produce oscillated output response.
Libau, Charles Muling
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Experimental study and theoretical analysis for the synchronous-concentric inclined pile composed of steel pipe pile and cemented soil

Frontiers in Earth Science
As a new type of composite pile, the synchronously and concentrically constructed steel pipe–cemented soil composite pile has been increasingly adopted as an inclined support system in foundation pit engineering.
Ye Jun-Neng, Wang Zhong-Jin, Zhu Kai-Chen, Shi Shi-Yong, Mao Hong-Hui, Wang Qian-Hao   +5 more
doaj   +1 more source

Mechanisms of mechanical load transfer through brain tissue. [PDF]

Sci Rep, 2023
Reiter N, Paulsen F, Budday S.
europepmc   +1 more source

The composite load spectra project [PDF]

Probabilistic methods and generic load models capable of simulating the load spectra that are induced in space propulsion system components are being developed.
Ho, H., Kurth, R. E., Newell, J. F.
core   +1 more source