Results 111 to 120 of about 1,221,101 (305)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Experimental study and theoretical analysis for the synchronous-concentric inclined pile composed of steel pipe pile and cemented soil

Frontiers in Earth Science
As a new type of composite pile, the synchronously and concentrically constructed steel pipe–cemented soil composite pile has been increasingly adopted as an inclined support system in foundation pit engineering.
Ye Jun-Neng, Wang Zhong-Jin, Zhu Kai-Chen, Shi Shi-Yong, Mao Hong-Hui, Wang Qian-Hao   +5 more
doaj   +1 more source

Mechanisms of mechanical load transfer through brain tissue. [PDF]

Sci Rep, 2023
Reiter N, Paulsen F, Budday S.
europepmc   +1 more source

Loading on the Scapho-Trapezium-Trapezoid joint during gripping [PDF]

, 2009
The scapho-trapezium-trapezoid (STT) joint is believed to be highly vulnerable to wear and has been identified clinically as a high risk joint in arthritic patients. A theoretical model [1] of the load transfer through the wrist during gripping, suggests
Gislason, M.K., Nash, D.H., Stansfield, B.W.   +2 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The composite load spectra project [PDF]

Probabilistic methods and generic load models capable of simulating the load spectra that are induced in space propulsion system components are being developed.
Ho, H., Kurth, R. E., Newell, J. F.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Analysis of bearing capacity of bored piles from bi-directional load test: A case study in Quang Ngai province

Journal of Materials and Engineering Structures, 2020
The paper presents the vertical bearing capacity of bored piles from the bi-directional load test (O-Cell method) at the Tra Khuc dam-bridge project in Quang Ngai province.
Dao Huu DO, Van-Ngoc PHAM, Anand J. PUPPALA, Duc-Manh NGUYEN   +3 more
doaj  

Review on Load Transfer Mechanisms of Asphalt Mixture Meso-Structure. [PDF]

Materials (Basel), 2023
Wang S, Yu W, Miao Y, Wang L.
europepmc   +1 more source

Influence of bond stress-slip relationship on bond strength prediction [PDF]

, 2015
The study of the bond stress-slip relationship of FRP (fibre reinforced polymer) adhered to concrete has been a key point to understand the bond behaviour of externally bonded reinforcement (EBR) and near surface mounted (NSM) systems.
Matthys, Stijn, Palmieri, Aniello, Proia, Alessandro   +2 more
core   +1 more source