Results 61 to 70 of about 3,483,119 (301)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
An evaluation of load balancing algorithms for distributed systems [PDF]
, 1991 Distributed systems are gradually being accepted as the dominant computing paradigm of the future. However, due to the diversity and multiplicity of resources, and the need for transparency to users, global resource management raises many questions.
Benmohammed-Mahieddine, Kouider
core +4 more sources
Geomatics, Natural Hazards & RiskExtensive coastal infrastructure construction has led to excavation failures causing social and economic losses. The heterogeneity, inter-layer interactions, and sensitivity of thick marine‑terrestrial soft soils complicate prediction and amplify 3D ...
Yongqin Li +4 more
doaj +1 more source
Wireless power transfer using Class E inverter with saturable dc-feed Inductor [PDF]
, 2014 Resonant converters used as coil drivers in inductive links generally operate efficiently at optimum switching conditions for constant load values and ranges. Changes in load and range can shift the operation of the coil driver to a non-optimum switching
Aldhaher, Samer +2 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Pile-soil stress ratio and settlement of composite ground with gravel piles in flexible foundation
Yantu gongcheng xuebao, 2017 The deformation mechanism of composite ground with gravel piles in flexible foundation is thoroughly studied, and the effect of a cross-sectional shear stress is introduced in the analysis of radial displacement mode considering the lateral bulging and ...
ZHAO Ming-hua , NIU Hao-yi , LIU Meng , TAN Xin
doaj +1 more source
Tuning class E inverters applied in inductive links using saturable reactors [PDF]
, 2014 This paper investigates the performance of Class E inverters used in wireless power transfer applications based on resonant inductive coupling. The variations in the load and the distance between the coils cause Class E inverters to operate in non ...
Whidborne, James F. +2 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Instrumentation and Axial Load Testing of Displacement Piles [PDF]
, 2013 Despite the fact that results of many instrumented pile load tests have been reported in the literature, it is difficult to find well-documented instrumentation procedures that can be used when planning a load testing programme.
Salgado, Rodrigo +4 more
core +1 more source