Results 71 to 80 of about 1,221,101 (305)

Analysis of Stress Relaxation in Jointed Plain Concrete Pavements

The Baltic Journal of Road and Bridge Engineering, 2015
The cracks in concrete pavements are formed at early-age as consequence of internal stresses in the concrete. Therefore, the stress relaxation has an essential influence on the cracking process. To model this process allows to identify, for instance, the
Mauricio Pradena, Lambert Houben
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Trajectory Tracking Control Strategy of 20-Ton Heavy-Duty AGV Considering Load Transfer

Applied Sciences
During the operation of outdoor heavy-duty Automated Guided Vehicle (AGV), the stability and safety of AGV are easily reduced due to load transfer.
Xia Li, Shengzhan Chen, Xiaojie Chen, Benxue Liu, Chengming Wang, Yufeng Su   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The High-Temperature Creep Behavior of In-Situ TiB₂ Particulate Reinforced Al12Si4Cu2NiMg Composite

Metals, 2018
In the present work, the in-situ TiB2/Al12Si4Cu2NiMg (denoted as ‘Al-12Si’) composites were successful synthesized through the salt-metal reaction route.
Shihan Dai, Zeyu Bian, Mingliang Wang, Yi Wu, Dong Chen, Hongping Li, Haowei Wang   +6 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Toward the Development of Load Transfer Efficiency Evaluation of Rigid Pavements by a Rolling Wheel Deflectometer

Infrastructures, 2020
The jointed rigid pavement is currently evaluated by the Falling weight deflectometer which is rather slow for the testing of the jointed pavements. Continuous nondestructive evaluation of rigid pavements with a rolling wheel deflectometer can be used to
Pawan Deep, Mathias B. Andersen, Nick Thom, Davide Lo Presti   +3 more
doaj   +1 more source

Load monitoring and output power control of a wireless power transfer system without any wireless communication feedback [PDF]

, 2013
For mid-range wireless power applications, the load is normally far away from the power source. In this project, a new method is proposed to determine the load impedance and load power without using any direct output feedback.
Hui, RSY, Lee, CK, Lin, D, Yin, J
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Heat transfer device [PDF]

, 1974
A heat transfer device is characterized by an hermetically sealed tubular housing including a tubular shell terminating in spaced end plates, and a tubular mesh wick concentrically arranged and operatively supported within said housing.
Kalkbrenner, R. W.
core   +1 more source