Results 71 to 80 of about 1,221,623 (254)
Dowel Bar Optimization: Phases I and II, October 2001 [PDF]
, 2001 America’s roadways are in serious need of repair. According to the American Society of Civil Engineers (ASCE), one-third of the nation’s roads are in poor or mediocre condition (1).
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Trajectory Tracking Control Strategy of 20-Ton Heavy-Duty AGV Considering Load Transfer
Applied SciencesDuring the operation of outdoor heavy-duty Automated Guided Vehicle (AGV), the stability and safety of AGV are easily reduced due to load transfer.
Xia Li +5 more
doaj +1 more source
Analysis of Stress Relaxation in Jointed Plain Concrete Pavements
The Baltic Journal of Road and Bridge Engineering, 2015 The cracks in concrete pavements are formed at early-age as consequence of internal stresses in the concrete. Therefore, the stress relaxation has an essential influence on the cracking process. To model this process allows to identify, for instance, the
Mauricio Pradena, Lambert Houben
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The High-Temperature Creep Behavior of In-Situ TiB2 Particulate Reinforced Al12Si4Cu2NiMg Composite
Metals, 2018 In the present work, the in-situ TiB2/Al12Si4Cu2NiMg (denoted as ‘Al-12Si’) composites were successful synthesized through the salt-metal reaction route.
Shihan Dai +6 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Summary of static load test of the Mod-0 blade [PDF]
A static load test was performed on the spare Mod-0 wind turbine blade to define load transfer at the root end of the blade, and to validate stress analysis of this particular type of blade construction (frame and stringer). Analysis of the load transfer
Miller, D. R.
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source