Results 191 to 200 of about 696,058 (264)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Fracture behaviour and structural integrity of hemp fibre reinforced composites for low load-bearing aerospace applications. [PDF]

Sci Rep
Nagaraja S, Anand PB, Kodandappa R, Frinjo A.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Effect of Mechanical Loading on Mitophagy in Aged Myoblasts. [PDF]

Cells
Tolis E, Chatzinikita E, Moustogiannis A, Giannopoulos A, Maridaki M, Koutsilieris M, Philippou A.   +6 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Experimental and Numerical Evaluation of Unsaturated Polyester Polymer Concrete for Highway Pavement Repair and Surface Rehabilitation. [PDF]

Polymers (Basel)
Arslannur B, Ozdemir MA, Cakir F.
europepmc   +1 more source

Biomechanical risk factors for tibial plateau fracture following Oxford unicompartmental knee arthroplasty: a finite element analysis under gait loading. [PDF]

Front Bioeng Biotechnol
Ji J, Xue L, Hou Y, Li Z, Tu Y, Xue H, Wen T, Yang T, Ma T.   +8 more
europepmc   +1 more source

Harnessing M1-Polarized Macrophage-Derived Extracellular Vesicles and Artificial Nanovesicles for Targeted Cancer Drug Delivery. [PDF]

Cells
Gangadaran P, Subramaniyan S, Rajendran RL, Hong CM, Swati K, Jha SK, Rashid S, Ahn BC.   +7 more
europepmc   +1 more source

Rehabilitation of the Severely Atrophic Maxilla with Subperiosteal Implants: A Biomechanical and Decision Analysis of Material and Configuration Choices. [PDF]

Biomimetics (Basel)
Türk BE, Bedirhandede B, Doğan DG, Güney B.   +3 more
europepmc   +1 more source