Results 191 to 200 of about 697,307 (264)

The Effect of Mechanical Loading on Mitophagy in Aged Myoblasts. [PDF]

Cells
Tolis E, Chatzinikita E, Moustogiannis A, Giannopoulos A, Maridaki M, Koutsilieris M, Philippou A.   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

What triggers seismicity thousands of kilometers away from a mainshock? [PDF]

Sci Adv
Huang C, Yang J.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mechanical Performance of Uncompatibilized Recycled Polypropylene Biocomposites Filled with Corn, Banana, and Barley Agro-Industrial Residue Fibers. [PDF]

Polymers (Basel)
García JF, Febres JD.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Experimental and Numerical Evaluation of Unsaturated Polyester Polymer Concrete for Highway Pavement Repair and Surface Rehabilitation. [PDF]

Polymers (Basel)
Arslannur B, Ozdemir MA, Cakir F.
europepmc   +1 more source

Biomechanical risk factors for tibial plateau fracture following Oxford unicompartmental knee arthroplasty: a finite element analysis under gait loading. [PDF]

Front Bioeng Biotechnol
Ji J, Xue L, Hou Y, Li Z, Tu Y, Xue H, Wen T, Yang T, Ma T.   +8 more
europepmc   +1 more source

Harnessing M1-Polarized Macrophage-Derived Extracellular Vesicles and Artificial Nanovesicles for Targeted Cancer Drug Delivery. [PDF]

Cells
Gangadaran P, Subramaniyan S, Rajendran RL, Hong CM, Swati K, Jha SK, Rashid S, Ahn BC.   +7 more
europepmc   +1 more source