Results 51 to 60 of about 832,826 (306)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fatigue life prediction of asphalt binders under variable loading levels based on dissipated pseudo-strain energy

Case Studies in Construction Materials
Miner’s criterion is popularized to develop the conventional fatigue life prediction model for estimating the service life corresponding to fixed loading level. However, the conventional model makes it difficult to recognize the significant dependency of
Chenze Fang, Hui Li, Zhenxia Li, Yuanzhao Chen, Tengteng Guo   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Fatigue crack growth rates under variable amplitude load spectra containing tensile underloads [PDF]

, 2003
An extensive research program was performed to investigate the load interaction effect of the combined action of small amplitude high R ratio cycles and large amplitude low R ratio underloads on the crack growth of large cracks.
Zitounis, Vasilios
core  

Valproate in status epilepticus: Correlation between loading dose, serum levels, and clinical response

, 2022
BACKGROUND AND PURPOSE: Intravenous valproate (VPA) is an established treatment of status epilepticus (SE), but optimal loading dose was not fully assessed.
Decosterd, Laurent A., André, P., Thierry Buclin, Andrea O. Rossetti, Decosterd, L.A., Sergiu Vijiala, Vijiala, S., Rossetti, A.O., Novy, Jan, Pascal André, Rossetti, Andrea O., Novy, J., Vijiala, Sergiu, Buclin, T., André, Pascal, Jan Novy, Laurent A. Decosterd, Buclin, Thierry   +17 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effects of knee loading on the mRNA and protein levels of tph2 in mouse brain.

, 2014
(A) mRNA levels of tph2 in the BS with knee loading, tail suspension, and knee loading followed by tail suspension. (B) Immunoblots displaying protein levels of tph2 and ß-actin in the BS of mice with knee loading.
Joseph M. Wallace (507061), Joon W. Shim (507058), Feng C. Zhou (394998), Todd R. Dodge (507059), Max A. Hammond (507060), Hiroki Yokota (507062)   +5 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Strength hardening and damage mechanism of semiwetted coal under cyclic loads with different initial stress levels

Scientific Reports
When a coal pillar serves as part of the dam structure in an underground coal mine reservoir, it is subjected to the combined effects of water immersion and dynamic loading. Therefore, understanding the mechanical properties of coal under such conditions
Feixiang Lv, Yong Zhang, Fanjie Kong, Xiaobin Li, Quanle Zou   +4 more
doaj   +1 more source