Results 81 to 90 of about 1,169,207 (357)

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu   +15 more
wiley   +1 more source

Home equity release for long term care financing: an improved market structure and pricing approach [PDF]

open access: yes, 2015
Home equity release products have been promoted as a potential solution to residential long term care costs for the elderly. Unexpectedly low utilization of home equity release loans has prompted efforts to better model and price the No-Negative-Equity ...
Andrews, Doug W., Oberoi, Jaideep S
core   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

open access: yesAdvanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song   +9 more
wiley   +1 more source

The Loan Puzzle. A Study of Loans to Different Groups in the USA

open access: yesSSRN Electronic Journal, 2020
We study loans from banking and non-banking lenders to different groups of borrowers in order to unveil significant differences on how those respond to a shock and evaluate possible alternative explanations for such differences. The objective is to gain insights useful to explain the loan puzzle: the unexpected increase of loans to firms in case of a ...
openaire   +3 more sources

LOAN WORDS AS SHAPERS OF IDENTITY IN SEVENTEENTHCENTURY MALAY: A HISTORICAL LINGUISTICS STUDY OF CHRISTIAN SONGS INTRODUCED BY THE VOC [PDF]

open access: yes, 2015
The presence of loan words in a language shows the long-standing interactions between that particular language as a recepient and its donors. Over time, these loan words are absorbed into the recipient language and they become a part of the linguistic ...
Thianto, Yudha
core  

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

open access: yesAdvanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen   +18 more
wiley   +1 more source

THE IMPACT OF THE 2008-2009 GLOBAL CRISIS ON RETAILERS’ AND CORE INDUSTRY FIRMS’ LOAN APPLICATIONS [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2023
The global crisis affected the financing conditions around the world. In this study, we examine two groups of firms in Eastern Europe and Central Asia: retailers and core industry firms.
HALIL DINCER KAYA
doaj  

Can Readability of Loan Description Affect Loan Success Rate and Loan Cost?: A Textual Analysis of P2P Loan Description

open access: yesEngineering Economics, 2020
Text is an important form of information transfer. In a P2P (Peer-to-Peer) loan market with severe information asymmetry, loan descriptive information voluntarily written by a borrower may generate significant influence on investors’ decision-making. As an important language feature, readability determines whether the audience can accurately identify ...
Usman Muhammad   +3 more
openaire   +3 more sources

Indian Contribution to Open Access Scholarly Publishing: A Case Study of DOAJ [PDF]

open access: yes, 2008
India has been a cradle of knowledge for thousands of years. Presently it has significant advantages in the 21st century knowledge race due to one of the largest higher education system in the world.
Loan, Fayaz Ahmad
core  

Credit constraints and the propagation of the Great Depression in Germany [PDF]

open access: yes, 2019
We evaluate the role played by loan supply shocks in the decline of investment and industrial production during the Great Depression in Germany from 1927 to 1932.
Adam, Marc C., Jansson, Walter
core   +1 more source

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