Results 61 to 70 of about 114,860,682 (209)

Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ

, 1997
Loss of expression of the intercellular adhesion molecule E-cadherin frequently occurs in invasive lobular breast carcinomas as a result of mutational inactivation. Expression patterns of E-cadherin and the molecules comprising the cytoplasmic complex of
Vos, C. B., Peterse, J. L., Cleton-Jansen, A. M., Cornelisse, C. J., Litvinov, S., van Roy, F., van de Vijver, M. J., de Leeuw, W. J., Berx, G.   +8 more
core   +1 more source

Immunoexpression of MED12 in lobular carcinoma in situ confined within fibroadenoma of breast

Human Pathology Reports
Fibroadenomas are common lesions in young women. Approximately 60–80% of fibroadenomas harbor a somatic mutation in exon 2 of the mediator complex MED12 subunit. MED12 regulates physiologic processes important for cell development. Dysregulation of MED12
James W. Perry, Kenneth A. Iczkowski, Cooley G. Pantazis, Amanda M. Burns   +3 more
doaj   +1 more source

Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies

Diagnostic Pathology, 2010
Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and ...
Bhargava Rohit, Yu Jing, Dabbs David J
doaj   +1 more source

Prevention of Early Onset of Breast Cancer With Ashwagandha

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm, Su‐Hyeong Kim, Shivendra V. Singh   +2 more
wiley   +1 more source

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Tissue fibrosis and its correlation with malignancy in canine mammary tumors

Revista Colombiana de Ciencias Pecuarias, 2018
Background: Fibrosis is present in several pathologies associated with mammary carcinogenesis. Objective: To evaluate and quantify the fibrosis present in malignant and benign mammary neoplasms in bitches.
Gabriela N. Toledo, Marcus A. R. Feliciano, Ricardo A. R. Uscategui, Geórgia M. Magalhães, Gabriela M. Madruga, Wilter R. R. Vicente   +5 more
doaj   +1 more source

Comparison of Long‐Term Health‐Related Quality of Life After Mastectomy and Breast Conserving Therapy

World Journal of Surgery, EarlyView.
Long‐term BREAST‐Q outcomes after breast‐conserving therapy (BCT) and mastectomy without reconstruction. Women treated with BCT reported higher psychosocial, sexual, and physical well‐being and greater satisfaction with their breasts than women treated with mastectomy.
Sanna Järvinen, Tiina Jahkola, Hanna Ihalainen, Jussi P. Repo, Susanna Kauhanen, Pauliina Homsy   +5 more
wiley   +1 more source

Deficient cell-cell cohesion is linked with lobular localization in simplified models of lobular carcinoma in situ (LCIS) [PDF]

Lobular carcinoma in situ (LCIS) is a precursor of invasive lobular carcinoma of the breast. LCIS cells lack cell-cell cohesion due to the loss of E-cadherin. LCIS cells grow in mammary lobules rather than in ducts.
Eisenburger, M., Christgen, M., Traulsen, A. ; https://orcid.org/, Altrock, P. ; https://orcid.org/, Caetano, R.   +4 more
core   +1 more source

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

Combined Contrast Enhanced Mammography and Digital Breast Tomosynthesis in Patients Suspected of Having Breast Cancer: A Prospective Comparison With Digital Mammography and Breast MRI—Findings of the CONTEST Study

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Introduction We aimed to assess diagnostic performance and accuracy for local staging of CEM combined with DBT (CE + DBT) compared to digital mammography (DM) and MRI. Methods Female patients aged 18–70 years with clinical or sonographic suspicion of breast cancer had CE + DBT and breast MRI prior to treatment.
Sarah L. Savaridas, Kulsam Ali, Sarah Vinnicombe, Petra Rauchhaus, Andrew J. Evans, Nisha Sharma, Sally Bolt, Patsy Whelehan   +7 more
wiley   +1 more source