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Evolving Concepts in the Management of Lobular Neoplasia
Journal of the National Comprehensive Cancer Network, 2006 Lobular neoplasia broadly defines the spectrum of changes within the lobule, ranging from atypical lobular hyperplasia (ALH) to lobular carcinoma in situ (LCIS). This continuum of lesions is associated with an increased risk for developing subsequent invasive breast cancer, with the magnitude of that risk corresponding to the degree of proliferative ...
Benjamin O, Anderson +2 more
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Surgical Clinics of North America, 2022
Lobular neoplasia (LN) is a term that describes atypical epithelial lesions originating in the terminal duct-lobular unit (TDLU) of the breast, including atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS). LN is both a risk factor and nonobligate precursor to invasive breast cancer.
Lilia, Lunt +2 more
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Lobular neoplasia (LN) is a term that describes atypical epithelial lesions originating in the terminal duct-lobular unit (TDLU) of the breast, including atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS). LN is both a risk factor and nonobligate precursor to invasive breast cancer.
Lilia, Lunt +2 more
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RadioGraphics, 2023
Lobular neoplasia (LN) is a histopathologic entity that encompasses both lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH). Management of LN is known to be variable and institutionally dependent. The variability in approach after a diagnosis of LN at percutaneous breast biopsy derives in part from heterogeneity in the literature ...
Samantha L. Heller, Yiming Gao
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Lobular neoplasia (LN) is a histopathologic entity that encompasses both lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia (ALH). Management of LN is known to be variable and institutionally dependent. The variability in approach after a diagnosis of LN at percutaneous breast biopsy derives in part from heterogeneity in the literature ...
Samantha L. Heller, Yiming Gao
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Surgical Oncology Clinics of North America, 2014
Lobular neoplasia (LN) is characterized by a dysfunctional E-cadherin-catenin axis, and loss of E-cadherin plays a causative role in the typical morphology of LN cells. LN is both a nonobligate precursor and a risk indicator of invasive breast cancer, and in particular, of invasive lobular carcinoma.
Tari A, King, Jorge S, Reis-Filho
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Lobular neoplasia (LN) is characterized by a dysfunctional E-cadherin-catenin axis, and loss of E-cadherin plays a causative role in the typical morphology of LN cells. LN is both a nonobligate precursor and a risk indicator of invasive breast cancer, and in particular, of invasive lobular carcinoma.
Tari A, King, Jorge S, Reis-Filho
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Current Diagnostic Pathology, 2004
Abstract Atypical lobular hyperplasia and lobular carcinoma in situ are lesions that occur relatively infrequently in the breast. They are also referred to under the umbrella term of ‘lobular neoplasia'. They have been recognized for over 60 years, with extensive characterization in the literature during that time. However, despite this long time span,
L.G Fulford, J.S Reis-Filho, S.R Lakhani
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Abstract Atypical lobular hyperplasia and lobular carcinoma in situ are lesions that occur relatively infrequently in the breast. They are also referred to under the umbrella term of ‘lobular neoplasia'. They have been recognized for over 60 years, with extensive characterization in the literature during that time. However, despite this long time span,
L.G Fulford, J.S Reis-Filho, S.R Lakhani
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The Evolution of Lobular Neoplasia
Advances in Anatomic Pathology, 2006Lobular neoplasia of the breast, encompassing both atypical lobular hyperplasia and lobular carcinoma in situ, remains a poorly understood entity. Often misconceived of as simply a risk factor for subsequent carcinoma, lobular neoplasia likely constitutes both a generalized risk factor and a direct precursor to invasive disease.
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Lobular and ductal intraepithelial neoplasia
Der Pathologe, 2008Lobular and ductal intraepithelial neoplasias reflect proliferations of immunophenotypically variable, biologically and morphologically diverse cells with a potential, not always realized, for progression to carcinoma by breaking through the barriers of the myoepithelial cell layer and basement membrane, ultimately invading the stroma.
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Management of Lobular Neoplasia
Current Breast Cancer Reports, 2018Lobular neoplasia (LN) is a well-established risk factor and non-obligate precursor for breast cancer. The clinical breast cancer risk assessment and management for these patients can be challenging. Numerous studies have confirmed that LN is a risk factor and non-obligate precursor for breast cancer.
Freya R. Schnabel +2 more
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Lobular Lesions (Lobular Neoplasia, Invasive Lobular Carcinoma)
2017Lobular breast lesions described in this chapter encompass a spectrum of conditions that share in common a proliferation of neoplastic lobular-type cells, which are morphologically rounded, mostly uniform cells with a tendency for discohesion.
Puay Hoon Tan, Aysegul A. Sahin
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