Results 111 to 120 of about 18,777,656 (308)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Impresa sociale ed empowerment territoriale per la formazione ed il lavoro
Journal of Educational, Cultural and Psychological Studies, 2018 The tumultuous processes of cultural and social changes that are transforming our country and society have led us to reflect on how we could understand and alleviate the problems these changes cause.
Massimiliano Smeriglio
doaj +1 more source
, 1975 Just a few men and women in the villages were well known for their voice and ability to sing these local songs. The songs were sung when people gathered together in someone’s house in the evening, tired from work, and at times of sadness and happiness ...
Wright, Susan
core +1 more source
Local overlaps, heterogeneities and the local fluctuation dissipation relations
, 2002 In this paper I introduce the probability distribution of the local overlap in spin glasses. The properties of the local overlaps are studied in details.
Aizenman M +23 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Local Homology and Local Cohomology
, 2004 Let $(R, {\frak m})$ be a local ring, $I$ a proper ideal of $R$ and $M$ a finitely generated $R$-module of dimension $d$. We discuss the local homology modules of $H^d_I(M)$. When $M$ is Cohen-Macaulay, it is proved that $H^d_{\frak m}(M)$ is co-Cohen-Macaulay of N.dimension $d$ and $H^{\underline{x}}_d(H^d_{\frak m}(M))\cong\hat{M}$ where $\underline ...
openaire +3 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
European Union: fears and hopes [PDF]
Eastern Journal of European Studies, 2016 This contribution analyses some data from Eurobarometer 83, spring 2015, especially to draw a map of Fears. The European Union is a divided space and one of the main consequences of the budget (financial) crisis of Greece, followed by the crisis caused ...
Gilles ROUET
doaj