Results 121 to 130 of about 18,777,656 (308)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Revista de Salud Ambiental, 2022 Dada la diversidad de contextos socioambientales en los que las personas se desenvuelven diariamente y en los que se han desencadenado diversos procesos de contaminación que afectan la salud humana, se vuelve necesario abordar la relación ser humano ...
Yordan Steven Brenes Vargas +1 more
doaj
, 2020 Exchangeability---in which the distribution of an infinite sequence is invariant to reorderings of its elements---implies the existence of a simple conditional independence structure that may be leveraged in the design of probabilistic models, efficient ...
Broderick, Tamara +4 more
core
How local are local lists? A quantitative and qualitative analysis of local lists in Flanders [PDF]
, 2013 Local party systems in Western democracies are characterized by the presence of so-called independent local lists, giving a distinct place-bound flavour to local politics.
Heyerick, An, Steyvers, Kristof
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Journal of Classics TeachingThe idea for this special issue of Journal of Classics Teaching arose from the conference ‘Monsters in the classroom: Latin and Greek at primary school’ which Steve Hunt (Cambridge), Lidewij Van Gils (Amsterdam), and myself (Ghent) co-organised in ...
Evelien Bracke
doaj +1 more source
, 2011 Framings provide a way to construct Quillen functors from simplicial sets to any given model category. A more structured set-up studies stable frames giving Quillen functors from spectra to stable model categories.
Barnes, D., Roitzheim, C.
core +5 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source