Results 61 to 70 of about 8,278,834 (319)

Locating Ben Okri’s The Age of Magic in a Cosmopolitan Framework [PDF]

open access: yesHyperCultura, 2020
In this paper, I explore the implications of the term “cosmopolitanism” and focus on the critical departures Kwame Anthony Appiah’s idea of “rooted cosmopolitanism” makes from the humanistic hue of cosmopolitanism.
Pooja Sancheti
doaj  

«La libertà è partecipazione»: la participación política local en Italia, entre normas y realidad

open access: yesEstudios de Deusto, 2021
Es común afirmar que la local representa la dimensión política más cercana a la ciudadanía y la más idónea para determinar, en lo cotidiano y en lo colectivo, su bienestar.
Ciro Milione
doaj   +1 more source

Local Government Excellence Programme prospectus – overview [PDF]

open access: yes, 2016
The 2015 New Zealand Local Government Survey found residents and businesses had a low awareness of the full services councils provide and the value they bring.
Local Government New Zealand
core  

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology

open access: yesMetabolites, 2018
Osteoarthritis (OA) is a progressive, deteriorative disease of articular joints. Although traditionally viewed as a local pathology, biomarker exploration has shown that systemic changes can be observed. These include changes to cytokines, microRNAs, and
Jason S. Rockel, Mohit Kapoor
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Articulación entre lo local y lo global. Templo Sagrada Familia en Barcelona

open access: yesUrbano, 2012
En la actualidad la articulación entre lo global y lo local adquiere una creciente y central importancia para el desarrollo equilibrado del territorio. La arquitectura juega un rol fundamental como articuladora de ambas escalas.
Patricia López Goyburu
doaj  

Local Reductions

open access: yes, 2015
We reduce non-deterministic time $T \ge 2^n$ to a 3SAT instance $ϕ$ of quasilinear size $|ϕ| = T \cdot \log^{O(1)} T$ such that there is an explicit circuit $C$ that on input an index $i$ of $\log |ϕ|$ bits outputs the $i$th clause, and each output bit of $C$ depends on $O(1)$ input bits. The previous best result was $C$ in NC$^1$.
Hamidreza Jahanjou   +2 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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