Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Frailty: a global health challenge in need of local action. [PDF]
Dlima SD +5 more
europepmc +1 more source
Planning our future: 8 point programme for a future-focused resource management system
This document is an eight point programme of action designed to address a range of important issues with New Zealand\u27s resource management system with the aim of furthering discussion about what would best suit the country\u27s needs in the coming ...
Local Government New Zealand
core
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Transformative capacity and local action for urban sustainability. [PDF]
Castán Broto V +3 more
europepmc +1 more source
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
A Holistic Response to Musculoskeletal Health: Implications for Global Health Policy Comment on "From Local Action to Global Policy: A Comparative Policy Content Analysis of National Policies to Address Musculoskeletal Health to Inform Global Policy Development". [PDF]
Lall D.
europepmc +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Local Action of Moderate Heating and Illumination Induces Electrical Signals, Suppresses Photosynthetic Light Reactions, and Increases Drought Tolerance in Wheat Plants. [PDF]
Yudina L +5 more
europepmc +1 more source

