Results 61 to 70 of about 17,695,991 (249)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A group of women shearing an alpaca.

, 2015
Freak freeze conditions in Peru Practical Action is working with remote indigenous Andean communities to help protect their alpacas and potato varieties to improve livelihoods and biodiversity thereby reducing vulnerability to climate change.
Practical Action Peru
core  

LEADER as a mechanism of neo-endogenous development of rural areas: the case of Poland

Miscellanea Geographica: Regional Studies on Development, 2020
The main aim of this paper is a quantitative and structural comprehensive evaluation of LEADER projects presented in the context of local resources, which determine development opportunities.
Biczkowski Mirosław
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Demographic Exploration of Associative Entities in the Local Action Group [PDF]

Ovidius University Annals: Economic Sciences Series
Demographic exploration within sustainable local development is pivotal for understanding associative entities in a specific region. This study delves into Romania's demographic views, with a focal point on Local Action Groups (LAGs) in Central ...
Anca Cristina Stanciu, Stefania-Rodica Hübel (Anghel) , Mari-Isabella Stan   +2 more
doaj  

Fostering Sustainability Transitions in Rural Areas: A Participatory Futuring Process

European Countryside
In recent years, policies have increasingly emphasized the need to support sustainability transitions. Aligned with this focus, scholars consider the circular economy a valuable strategy for advancing sustainable development.
Santo Naomi di, Negro Simona, Sisto Roberta   +2 more
doaj   +1 more source

The Leader Programme as an Impulse for New Projects in Rural Areas

Quaestiones Geographicae, 2018
The article aims to present the stages of the LEADER programme and its influence on greater activity and integration of inhabitants by, e.g. extending the knowledge of tradition and national heritage and the actions intended for the integration of local ...
Hoffmann Robert, Hoffmann Natalia
doaj   +1 more source

The role of farmers in Local Action Groups: The case of the national network of the Local Action Groups in the Czech Republic

Agricultural Economics (AGRICECON), 2012
The social inclusion of different rural population groups is one of the objectives of the Rural Development Programme of the Czech Republic for the period of 2007-2013.
Miloslav DELIN
doaj   +1 more source