Results 81 to 90 of about 17,695,991 (249)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
In the foreground, a woman smiling at an alpaca. In the background, a group of people.
, 2015 Freak freeze conditions in Peru Practical Action is working with remote indigenous Andean communities to help protect their alpacas and potato varieties to improve livelihoods and biodiversity thereby reducing vulnerability to climate change.
Practical Action Peru
core
Information sheet 'Action Group for Irish Youth training service' [PDF]
Document listing the topics covered by training courses offered by the Action Group for Irish Youth (AGIY)
Action Group for Irish Youth +1 more
core +4 more sources
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
A large group of natives posing for a photo, with the hills in the background.
, 2015 Freak freeze conditions in Peru Practical Action is working with remote indigenous Andean communities to help protect their alpacas and potato varieties to improve livelihoods and biodiversity thereby reducing vulnerability to climate change.
Practical Action Peru
core
Tér–Gazdaság–EmberThe present study sought to answer the question of how sustainability was achieved in the development of a rural micro-region. One of the instruments for sustainability is the LEADER programme, implemented by local/regional civil society, business and ...
Eszter Horváth +2 more
doaj +1 more source
Hungarian Geographical Bulletin, 2017 History is a construct based on the reselection, reconstruction and reinterpretation of past events in order to validate former, present, as well as future actions of actors.
Michal Semian, Aleš Nováček
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
, 2015 In the Andean province of Canchis, the main activity is raising alpacas, llamas and sheep and growing native potatoes. On average, each family owns 50 alpacas or llamas, obtaining an income of about $300 a year.
Practical Action Peru
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