Results 151 to 160 of about 411,643 (264)

A method for identifying local adaptation in structured populations. [PDF]

PLoS Genet
do O I, Gaggiotti OE, de Villemereuil P, Goudet J.   +3 more
europepmc   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Putative Genomic Signatures of Local Adaptation in Five Local Indonesian Sheep Reveal Selection on Immunity, Reproduction, and Production Traits. [PDF]

Ecol Evol
Astuti PK, Mizeranschi AE, Herdis H, Sitaresmi PI, Ibrahim A, Prastowo S, Widyas N, Nugroho T, Kusza S.   +8 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Local adaptation to climate has facilitated the global invasion of cheatgrass. [PDF]

Nat Commun
Gamba D, Vahsen ML, Maxwell TM, Pirtel N, Romero S, Van Ee JJ, Penn A, Das A, Ben-Zeev R, Baughman O, Blaney CS, Bodkins R, Budha-Magar S, Copeland SM, Davis-Foust SL, Diamond A, Donnelly RC, Dunwiddie PW, Ensing DJ, Everest TA, Hoitink H, Holdrege MC, Hufbauer RA, Juzėnas S, Kalwij JM, Kashirina E, Kim S, Klisz M, Klyueva A, Langeveld M, Lutfy S, Martin D, Merkord CL, Morgan JW, Nagy DU, Ott JP, Puchalka R, Pyle LA, Rasran L, Rector BG, Rosche C, Sadykova M, Shriver RK, Stanislavschi A, Starzomski BM, Stone RL, Turner KG, Urza AK, VanWallendael A, Wegenschimmel CA, Zweck J, Brown CS, Leger EA, Blumenthal DM, Germino MJ, Porensky LM, Hooten MB, Adler PB, Lasky JR.   +58 more
europepmc   +1 more source

Problematic Internet Use in Frontotemporal Dementia: A Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The present study investigated problematic internet use (PIU) among 61 patients with frontotemporal dementia (FTD) compared to a cohort of 354 patients with mild cognitive impairment (MCI) and Alzheimer's dementia. PIU was identified in 22.9% of FTD patients compared to only 0.8% of AD patients (p < 0.001). Behaviors included compulsive social
Daniele Urso, Giuseppe Volpe, Agnese Valguarnera, Davide Vilella, Alessandra Vitulli, Valentina Gnoni, Alessia Giugno, Eleonora Rollo, Mark D. Griffiths, Giancarlo Logroscino   +9 more
wiley   +1 more source

Correction to 'The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch'. [PDF]

Ecol Evol
europepmc   +1 more source

Epigenetic signatures of local adaptation: differential expression of long non-coding RNAs in reciprocally transplanted <i>Mytilus chilensis</i>. [PDF]

Front Immunol
Yévenes M, Gonzalo G, Gallardo-Escárate C.   +2 more
europepmc   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Causes and consequences of bacterial local adaptation via MGEs in the plant microbiome. [PDF]

New Phytol
Porter S, Holtappels D, Montoya A, Koskella B.   +3 more
europepmc   +1 more source