Results 131 to 140 of about 482,757 (314)
Everyday realities of climate change adaptation in Mozambique
, 2012 This paper analyzes discourses and practices of flood response and adaptation to climate change in Mozambique. It builds on recent publications on climate change adaptation that suggest that the successes and failures of adaptation highly depend on the ...
Hilhorst, Dorothea +3 more
core +1 more source
Localized Adaptive Risk Control
Advances in Neural Information Processing Systems 37Adaptive Risk Control (ARC) is an online calibration strategy based on set prediction that offers worst-case deterministic long-term risk control, as well as statistical marginal coverage guarantees. ARC adjusts the size of the prediction set by varying a single scalar threshold based on feedback from past decisions.
Matteo Zecchin, Osvaldo Simeone
openaire +3 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Scenarios and Sustainability A Swedish Case Study of Adaptation Tools for Local Decision-Makers [PDF]
Adaptation to climate change often involves long time frames and uncer-tainties over consequences of chosen adaptation measures. In this study, two tools developed for assisting local decision-makers in adaptation planning were tested: socio-economic ...
Carlsen, Henrik +3 more
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Rethinking disaster risk management and climate change adaptation [PDF]
, 2013 Australian governments face the twin challenges of dealing with extreme weather-related disasters (such as floods and bushfires) and adapting to the impacts of climate change.
Deanna Grant-Smith +2 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Ecology and Evolution, 2019 Identifying traits and agents of selection involved in local adaptation is important for understanding population divergence. In southern Sweden, the moth‐pollinated orchid Platanthera bifolia occurs as a woodland and a grassland ecotype that differ in ...
Judith Trunschke +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Aboriginal responses to climate change in arid zone Australia [PDF]
, 2013 Given the broad scale and fundamental transformations occurring to the natural environment due to anthropogenic climate change in the present era, what does the future hold for Aboriginal people in remote arid regions of Australia? In searching for
Brian Head, Paul Memmott, Joseph Reser
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