Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
THE PROCESS OF DECENTRALIZATION IN BULGARIA AND THE NECESSITY OF INTRODUCING REGIONAL SELF-GOVERNMENT [PDF]
In the recent years many Central and Eastern European Countries (CEEC) are re-arranging their regional levels of administration. After the political transition, the newly established democratic governments and parliaments focused on the establishment of ...
Yuliyana Chavdarova Galabinova
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Challenges to democratic legitimacy, scrutiny, accountability in the UK national and local state [PDF]
, 2008 This article suggests that at national and local levels, the British state is seemingly incapable of solving multi-faceted and intractable social, economic and environmental problems alone. It is argued that new national and local governance arrangements,
Liddle, J
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Mucoadhesive Nanoparticles Enhance the Therapeutic Effect of Dexamethasone on Experimental Ulcerative Colitis by the Local Administration as an Enema. [PDF]
Drug Des Devel Ther, 2023 Dong K +9 more
europepmc +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Local administration of amyloid enhancing factor initiates in situ amyloid A deposition followed by systemic lesions in mice. [PDF]
Exp Anim, 2023 Iwaide S +3 more
europepmc +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Effect of Systemic Administration of CD4+ T cells and Local Administration of T-cell Stimulants on T-cell Activity in Psoriatic Skin Xenografts on NOG Mice. [PDF]
Comp Med, 2023 Christensen PK +5 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu +14 more
wiley +1 more source
Application Areas of the Shared Service Concept within the Romanian Health System [PDF]
The Romanian healthcare system can be characterized by chronic under financing, leading to poor services towards the patients, corruption and high debts of the public institutions towards their suppliers. In order to cope with the situation, the Romanian
Martin WENDEROTH
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