Results 121 to 130 of about 3,962,313 (317)

Effect of local administration of injectable platelet-rich fibrin on root resorption during orthodontic tooth movement in dogs. [PDF]

Dent Res J (Isfahan), 2023
Sedaghati G, Feizbakhsh M, Esnaashari N, Razavi SM.   +3 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Protein engineering to overcome limitations of key cytokines in cancer immunotherapy: current approaches and future perspectives

Immuno-Oncology and Technology
Given their central role in immune regulation, cytokines have long been considered attractive therapeutic agents, particularly in cancer immunotherapy.
U. Salazar, P. Cioffi, B. Taskoparan, I. Moraga, S. Mitra, J. vom Berg   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Bailouts in Costa Rica as a Result of Government Centralization and Discretionary Transfers [PDF]

This paper investigates the inter-relation between the central government and the municipalities in Costa Rica. It examines episodes in which the central government has bailed out the local governments from their obligations.
Alexander Monge-Naranjo, Gilberto E. Arce, Luis J. Hall   +2 more
core  

Effects of early local administration of high-dose bFGF on a recurrent laryngeal nerve injury model. [PDF]

J Otolaryngol Head Neck Surg, 2023
Goto T, Ueha R, Sato T, Yamasoba T.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Enhancing the efficiency of local government in the context of reducing the administrative expenditures [PDF]

The concerns on enhancing the efficiency of public administration, in particular the local government, are moreover present in the concerns of local authorities and specialised literature.
Matei, Ani, Savulescu, Carmen
core   +1 more source

Local administration of vancomycin powder in orthopaedic fracture surgery: current practice and trends. [PDF]

OTA Int, 2023
Marchand LS, Sprague S, O'Hara NN, Li CS, O'Toole RV, Joshi M, Viskontas D, Romeo N, Hymes RA, Obremskey WT, Higgins TF, Potter GD, Bergin PF, Gage M, Gary JL, Bhandari M, Slobogean GP.   +16 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source