Results 101 to 110 of about 3,962,313 (317)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Post-decentralization regional economies and actors -- putting the capacity of Local governments to the test [PDF]
Decentralization in Indonesia was introduced institutionally in 2001, with a democratization drive promoted by international donors and by the intention of the new government to clear away the centralistic image of Soeharto. Decentralization has had some
Matsui, Kazuhisa
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
INTEGRATED GOVERNANCE – A REAL STRATEGIC OPTION FOR AN EFFECTIVE ROMANIAN LOCAL PUBLIC ADMINISTRATION [PDF]
Based on the fact that governance is referring to the processes of governing which includes all public management organizations, the paper contains some opinions of the specialists concerning governance and integrated governance concept.
Armenia ANDRONICEANU
core
Data warehouse - opportunity for local authorities [PDF]
, 2004 Local government exists in a very complex organizational environment, which has been subjected to an ever increasing pace of changes. This situation has generated a huge impact on the local government's reaction towards two major elements in is ...
Šimonová, Stanislava
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Semblante jurídico de la democracia deliberativa local y sus aspectos polémicos
Revista Vasca de Administración Pública, 2017 The current system of local participation reflects the legal shadows of deliberative democracy, with projection in the constitutional sphere. The analysis of controversial aspects such as the questionable nature of participatory rights, the regulation by
Catalina Ruiz-Rico Ruiz
doaj +1 more source
Developing a Philippine Local Government Bond Market [PDF]
The 1991 Local Government has initiated comprehensive changes in Philippine public administration such as decentralization and greater local autonomy. However, the macroeconomic picture has been characterized by volatile inflation, foreign exchange and ...
Laya, Jaime C.
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source