Results 91 to 100 of about 1,369,139 (317)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Semblante jurídico de la democracia deliberativa local y sus aspectos polémicos

Revista Vasca de Administración Pública, 2017
The current system of local participation reflects the legal shadows of deliberative democracy, with projection in the constitutional sphere. The analysis of controversial aspects such as the questionable nature of participatory rights, the regulation by
Catalina Ruiz-Rico Ruiz
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

ETHNIC POLITICS AND SUSTAINABLE DEMOCRACY IN NIGERIA

International Studies Journal
Since Nigeria gained independence, there has been a persistent demand for an electoral system that would foster a functional democratic process. Despite numerous reform efforts, the outcome appears to deteriorate with each successive general election ...
UKWU FELIX EMEKA
doaj  

From the history of voivodeship administration in the Middle Volga region: 1693

Из истории и культуры народов Среднего Поволжья
The article presents the voivodes governed the districts in the Middle Volga in 1693. The author has analyzed the composition of local rulers based on the collections of documents and archival materials, characterized the main directions of their ...
Dmitry Viktorovich Basmantsev
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Development and Antitumor Evaluation of Doxorubicin-Loaded Two-Layered Sheets for Local Chemotherapy via Direct Drug Application to the Tumor Surface

Pharmaceutics
Background/Objectives: Non-specific distribution of anticancer drugs to non-lesional areas of the body and organs, followed by their rapid disappearance, limits the drug concentration in the tumor, impacting the chemotherapy efficacy.
Nao Mitsudome, Mayuko Matsumoto, Yui Murakami, Fei Yuan, Hirotaka Miyamoto, Shintaro Fumoto, Akira Toriba, Koyo Nishida   +7 more
doaj   +1 more source

Local Administration of Minocycline Improves Nerve Regeneration in Two Rat Nerve Injury Models. [PDF]

Int J Mol Sci, 2023
Guillemot-Legris O, Girmahun G, Shipley RJ, Phillips JB.   +3 more
europepmc   +1 more source