Results 71 to 80 of about 1,369,139 (317)
Assessing the Energy Crisis in South Africa: The Socio-Economic Implication and Challenges Ahead [PDF]
E-Journal of Humanities, Arts and Social SciencesThis paper examined the socio-economic implications caused by the current energy crisis South Africa is facing. Although the crisis is not at its worst stage when compared to other countries in Africa, there are still challenges ahead if the crisis at ...
Kazeem Oyedele Lamidi +1 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Теорія і практика правознавства, 2016 Problem Setting. The article studies the question of responsibility of officials of local administrations for violations in the sphere of land relations. The analysis of scientific papers in the study area, considered issues related to the classification
А. С. Самородов
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
AntibioticsBackground/Objectives: To evaluate the effectiveness of local antibiotic prophylaxis (e.g., powder, bone cement, intraosseous injection) in reducing periprosthetic joint infections (PJI) and deep wound infections in adults undergoing primary joint ...
Chia-Yu Lin +6 more
doaj +1 more source
Управленческое консультирование, 2019 The article is devoted to research of the legal bases regulating the principles of the organization of local government in the Russian Federation, provided by the Federal law of 28.08.1995 N 154-FZ and the Federal law of 06.10.2003 N 131-FZ.
Yu. V. Vasilyeva
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Local Management and New Public Management
Central European Public Administration Review, 2011 Economic globalization, growingly differentiated and unstable markets, fiscal crises in light of increasing public expenditure are the elements of an uncertain future for local communities.
Irena Bačlija
doaj +1 more source
Challenges to democratic legitimacy, scrutiny, accountability in the UK national and local state
, 2008 This article suggests that at national and local levels, the British state is seemingly incapable of solving multi-faceted and intractable social, economic and environmental problems alone. It is argued that new national and local governance arrangements,
Liddle, J
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