Results 51 to 60 of about 8,834,903 (313)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Revista Crítica de Ciências Sociais, 2007 A critical analysis is undertaken of the risks resulting from the existence of a variety of local political players in Mozambique, who, in addition to their involvement in district and local government, fill political and/administrative positions in the ...
Tiago Matos Fernandes
doaj +1 more source
Guidelines on sustainable mobility : walkability and accessibility
, 2023 This is the third published guideline document, in a series of documents which are being published under the Resident First project headed by the Local Councils’ Association and endorsed by all Local Councils in Malta and Gozo.
Zammit, Antoine +1 more
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Asian Review of Public AdministrationIn the first quarter of the 21st century, digital transformation emerged as a key catalyst for reshaping public administration systems across Asia. This study examines the transition of public financial management (PFM) systems toward digitalization in ...
Dhanabhadr Sookhdee
doaj +1 more source
Bonneville Power Administration 1998 Annual Report.
, 1998 This is the 1998 annual report to the President by the Administrator and Chief Executive Officer of the Bonneville Power Administration. The topics of the report include financial highlights, letter to the President, review of 1998, financial data ...
United States. Bonneville Power Administration.
core +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Journal of Governance and Public PolicyThe management of Hol Sulamadaha Bay in Ternate City remains suboptimal, as reflected in the declining number of tourists visits due to the lack of prioritization in development efforts.
Alma'arif Alma'arif +2 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source