Results 121 to 130 of about 289,917 (314)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
THE PROCESS OF DECENTRALIZATION IN BULGARIA AND THE NECESSITY OF INTRODUCING REGIONAL SELF-GOVERNMENT [PDF]
In the recent years many Central and Eastern European Countries (CEEC) are re-arranging their regional levels of administration. After the political transition, the newly established democratic governments and parliaments focused on the establishment of ...
Yuliyana Chavdarova Galabinova
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Silicon utopias: the making of a tech startuo ecosystem in Manchester (UK) [PDF]
, 2017 ‘Silicon utopias’, the hope for a green, affluent and happy future through the creation of new tech-businesses, are today informing many urban development processes globally.
Pfeilstetter, Richard
core
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Turkish Voter Response to Government Incompetence and Corruption Related to the 1999 Earthquakes [PDF]
The two major earthquakes which struck northwestern Turkey in 1999, caused enormous amounts of death and destruction, and exposed rampant government corruption involving construction and zoning code violations, as a factor magnifying the disaster.
Ali T. Akarca, Aysit Tansel
core +3 more sources
The Elaboration Stages of Local Development Strategies
Revista Transilvană de Ştiinţe Administrative, 2003 This article - “The Elaboration Stages of Local Development Strategies” - aims to present a topic of current interest for Romanian local public administrations.
Márton BALOGH
doaj
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source