Results 51 to 60 of about 5,960,966 (303)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The future is local? Contextualizing municipal agendas on climate change in Chile
npj Climate ActionSocial science literature on the political strategies used to mitigate and adapt to climate change has discussed the possibilities of local administrations and the multifaceted obstacles in their path.
Rosa Lehmann, Alejandra Irigoyen Rios
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Personalized extended government for local public administrations
, 2015 This paper discusses the enterprise organization environment and reports our experience and lessons learned in developing an extension of the traditional virtual enterprise model, we named personalized extended government (PEG) model.
Biancalana C. +2 more
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Теорія і практика правознавства, 2016 Problem Setting. The article studies the question of responsibility of officials of local administrations for violations in the sphere of land relations. The analysis of scientific papers in the study area, considered issues related to the classification
А. С. Самородов
doaj +1 more source
Revista Vasca de Administración Pública, 2021 This paper analyses the legal legitimacy of articles 61 and 62 of the Royal Decree 128/2018, of March 16, regulating the legal regime of Local Administrations¿ civil servants with a national habilitation.
Antonio Ezquerra Huerva
doaj +1 more source
Carte générale des grandes communications télégraphiques du monde [cartographic material] /
, 1885 Map of the world showing the routes of telegraph lines in 1885 that connected continents and allowed rapid telecommunication, even to Australia.; Prime meridian: Greenwich.; Also available in an electronic version via the Internet at: http://nla.gov.au ...
Bureau International des Administrations Télégraphiques
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source