Results 171 to 180 of about 6,358,445 (212)

Safety of Damoctocog Alfa Pegol in Patients With Severe Haemophilia A Aged 7 to <12 Years of Age: Pooled Data From PROTECT VIII Kids and Alfa‐PROTECT

Haemophilia, EarlyView.
Margareth C. Ozelo, Anthony K. C. Chan, Matteo Luciani, Monika Maas Enriquez, Claudia Tueckmantel, Maria Elisa Mancuso   +5 more
wiley   +1 more source

Tin Sensitization in Belgium and the Netherlands: Complementary Findings From Two Independent Retrospective Studies

Contact Dermatitis, Volume 95, Issue 6, Page 538-544, December 2026.
In retrospective studies the prevalence of tin sensitization and its clinical relevance was evaluated in two groups: consecutive patients and patients suspected of metal allergies. The prevalence was higher than previously reported and relevance could be established for ~30%.
Sylvie M. Franken, Hannelore George, Isha C. Anwar, Ella Dendooven, Olivier Aerts, Thomas Rustemeyer   +5 more
wiley   +1 more source

Shikonin: From Biosynthesis and Pharmacological Mechanisms to Translational Safety and Drug Delivery

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Shikonin, biosynthesised in Boraginaceae roots from phenylalanine‐derived PHB and isoprenoid GPP, modulates redox balance, cellular stress, signalling pathways, and regulated cell death. Preclinical studies support diverse pharmacological activities, while nanocarriers improve dispersion and delivery.
Namini Joshi, Prabhakar Semwal, Balwant Rawat, Ravendra Kumar, Mozaniel Santana de Oliveira, Nishant Rai, Janhvi Mishra Rawat   +6 more
wiley   +1 more source

Efficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review

International Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1342-1351, November 2026.
ABSTRACT Background Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS.
Arun Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace, Jeffrey Suh, Jivianne Lee, Marilene Wang, Sarah Wise, Naweed Chowdhury, Zachary M. Soler, Justin Turner, Timothy L. Smith, Myung Sim, Daniel M. Beswick   +13 more
wiley   +1 more source

A Current Evidence Review From the Italian Society of Pediatric Allergology and Immunology (SIAIP) on Practical Management of Allergic Rhinitis in Children and Adolescents

Clinical and Translational Allergy, Volume 16, Issue 11, November 2026.
ABSTRACT Background Allergic rhinitis (AR) is highly prevalent in children and adolescents and impairs quality of life, sleep, and school performance, while also worsening asthma control. The last EAACI position paper on pediatric AR was published in 2013.
Giorgio Ciprandi, Amelia Licari, Cristiana Indolfi, Sara Manti, Michele Miraglia del Giudice, Maria Angela Tosca, Anna Maria Zicari, Gianluigi Marseglia   +7 more
wiley   +1 more source

Staphylococcus aureus‐derived xanthine exacerbates allergic rhinitis‐induced olfactory dysfunction through promoting Th17 cell differentiation and IL‐17A production

Clinical &Translational Immunology, Volume 15, Issue 11, 2026.
Staphylococcus aureus‐derived xanthine exacerbates allergic rhinitis‐associated olfactory dysfunction by promoting Th17 cell differentiation and IL‐17A production. IL‐17A neutralisation alleviates olfactory sensory neuron loss and improves olfactory function. Abstract Objectives Allergic rhinitis (AR) is frequently accompanied by olfactory dysfunction (
Yue Hu, Wenjing Wang, Ting Yang, Xiaoyu Song, Yao Wang, Yuanchao Cheng, Yakui Mou, Chao Ren, Xicheng Song   +8 more
wiley   +1 more source

The Role of Mitochondrial Homeostasis in the Pathogenesis of Chronic Rhinosinusitis

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
The vicious cycle between pathogenic factors‐induced inflammation, oxidative stress, and mitochondrial dysfunction in the context of chronic rhinosinusitis. Created in BioRender. Taghizadeh‐Hesary (2026) https://BioRender.com/k5f4t1f. ABSTRACT Background Chronic rhinosinusitis (CRS) is a common clinical condition characterized by persistent ...
Babak Ghalehbaghi, Morteza Fallahpour, Mohammad Nabavi, Maryam Jalessi, Hadi Ghanbari, Nasibeh Khayer, Farzad Taghizadeh‐Hesary   +6 more
wiley   +1 more source

Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat‐Dose Administration for up to 14 Days

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 10, Page 1390-1401, November 2026.
In this Phase 1 study, linaprazan glurate (LG) demonstrated rapid onset of intragastric acid suppression, achieving a pH > 4 within 10 to 60 min, and maintained pH control, with a 24‐h pH > 4 holding time ratio above 95% at 50 mg and 75 mg twice‐daily doses. AUC and Cmax of linaprazan, the main metabolite of LG, increased in proportion to LG dose.
Kajsa Larsson, Kjell Andersson, Gunilla Huledal, Jouni Junnila, Kristofer Katkits Nilsson, Elham Yektaei, Matjaž Fležar, Peter Unge   +7 more
wiley   +1 more source

Antibiotic Prophylaxis and Surgical Site Infections in Septoplasty

Clinical Otolaryngology, Volume 51, Issue 6, Page 888-893, November 2026.
ABSTRACT Background Surgical site infection is one of the most common complications of septoplasty. The use of antibiotic prophylaxis has been debated for years. Since the practice at our centre has shifted towards a more frequent use of prophylactic antibiotics in septoplasties, our aim was to review its use and effect on the postoperative infection ...
Sara Sainio, Elin Fierens, Antti Mäkitie, Markus Lilja, Morag Tolvi, Marie Lundberg   +5 more
wiley   +1 more source

Nasal Obstruction Is Reduced 5–7 Years After Radiofrequency Turbinate Reduction: Results From a Retrospective Observational Cohort Study

Clinical Otolaryngology, Volume 51, Issue 6, Page 914-922, November 2026.
ABSTRACT Introduction Nasal obstruction, often caused by structural and inflammatory conditions, is prevalent and significantly impacts health‐related quality of life. Radiofrequency Turbinate Reduction (RFTR) is a widely employed treatment for inferior turbinate hypertrophy, yet evidence of its long‐term effectiveness remains limited. This study aimed
Veronica Ahlund, Pål Rosholm Comstedt, Maria Värendh, Pernilla Sahlstrand‐Johnson   +3 more
wiley   +1 more source