Results 61 to 70 of about 6,358,445 (212)

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

Nasal Administration of Lipopolysaccharide Exacerbates Allergic Rhinitis through Th2 Cytokine Production from Mast Cells

, 2021
Background: Microbial infection or exposure to endotoxin later in life exacerbates established asthma. Mast cells are involved in the exacerbation of asthma. This exacerbation involves a toll-like receptor (TLR)–mediated response of mast cells.
Ichiro Morikura, Hideyuki Kawauchi, Noriaki Aoi, Tatsunori Sakamoto, Takafumi Fuchiwaki   +4 more
core   +1 more source

Acupuncture Alleviates Allergic Rhinitis by Activating the AMPK/PGC‐1α Pathway to Attenuate Mitochondrial Oxidative Stress and Restore Epithelial Barrier Function

Flavour and Fragrance Journal, EarlyView.
Acupuncture at Feishu (BL13), Shenshu (BL23), Yingxiang (LI20), and Dazhui (GV14) alleviates allergic rhinitis by activating the AMPK/PGC‐1α/NRF1/TFAM signalling axis. This activation improves mitochondrial biogenesis and function, reduces mtROS‐mediated oxidative stress, restores ATP production and respiratory complex I/IV activity, suppresses IgE and
Fengying Zhang, Wei Meng, Renzhong Wang, Huijun Du   +3 more
wiley   +1 more source

From nasal cytology to cellular endotyping: mast cell–eosinophil interactions and overlapping inflammation in allergic rhinitis

Frontiers in Immunology
Allergic rhinitis is traditionally defined by allergen sensitization and type 2 inflammation, yet increasing evidence indicates that this framework does not fully capture the biological heterogeneity of the nasal mucosa.
Matteo Gelardi
doaj   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

Association of the nasopharyngeal microbiota with the level of secretory IgA in children with suspected local allergic rhinitis: a pilot study

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Local allergic rhinitis is a distinct nosological entity whose immunopathogenetic mechanisms and phenotypic heterogeneity are currently being actively studied.
N.P. Lakomska, O.V. Sharikadze, S.O. Zubchenko   +2 more
doaj   +1 more source

Fecal microbiota transplantation and microbiota‐based therapeutics in pediatric clinical practice: Current status and emerging indications

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Fecal microbiota transplantation (FMT) is a safe and effective treatment for recurrent or refractory Clostridioides difficile infection (rCDI) in children and adults. This review outlines the evidence behind FMT for rCDI, considerations in special pediatric populations, and limitations in current practice due to FMT access for patients under ...
Nikhil Pai, Maribeth Nicholson, Steven Rich, Máire A. Conrad   +3 more
wiley   +1 more source

Effects of BCG Vaccination Prior to Specific Immunotherapy on IL-4/IFN-γ Ratio and AR Total Symptom Score in Persistent Allergic Rhinitis (Efek vaksinasi BCG pre imunoterapi spesifik terhadap rasio IL-4/IFN-γ dan skor gejala total rinitis pada rinitis alergi persisten) [PDF]

, 2009
Background: Allergic disease including allergic rhinitis (AR) is dominated by Th2 responses with increased production of IL-4 and inhibition of IFN-ï§ production. BCG vaccination induced IL-12 production which promotes Th0 to Th1 shift and stimulates IFN-
Suprihati , Suprihati
core   +1 more source

The Effectiveness of Sublingual Allergen-Specific Immunotherapy in Children with Allergic Rhinitis

Zdorovʹe Rebenka, 2015
The article analyses the effectiveness of sublingual allergen-specific immunotherapy with sublingual house dust mite and pollen allergens (early and late spring and autumn grass mixture) in patients with seasonal allergic rhinitis, perennial allergic ...
M.P. Prokhorova
doaj   +1 more source

Local allergic rhinitis: nasal allergen provocation testing as a good tool in the differential diagnosis.

International Journal of Occupational Medicine and Environmental Health, 2020
Local allergic rhinitis (LAR) is a specific phenotype of allergic rhinitis. One characteristic feature of LAR is a medical history indicative of an allergic disease, negative skin-prick test results, undetectable levels of specific IgE, and a positive ...
O. Wojas, B. Samoliński, E. Krzych-Fałta   +2 more
semanticscholar   +1 more source