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Benzonatate as a local anesthetic. [PDF]

open access: yesPLoS One, 2023
Introduction Benzonatate is an FDA-approved antitussive agent that resembles tetracaine, procaine, and cocaine in its chemical structure. Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local ...
McGuire A   +4 more
europepmc   +5 more sources

The thermodynamics of general and local anesthesia [PDF]

open access: yesBiophys. J. 2014, 106: 2143-2156, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare   +2 more
arxiv   +4 more sources

Clinical pain evaluation with intraoral vibration device during local anesthetic injections [PDF]

open access: yesJournal of Clinical and Experimental Dentistry, 2015
Objectives: To evaluate the clinical pain during local anesthetic injection using such intra-oral device. Study Design: A comparative split-mouth clinical study to evaluate clinical pain was conducted among the subjects who required bilateral local ...
Bhardwaj, Savita   +4 more
core   +3 more sources

Intravenous lipid emulsion in clinical toxicology [PDF]

open access: yesScandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2010
Intravenous lipid emulsion is an established, effective treatment for local anesthetic-induced cardiovascular collapse. The predominant theory for its mechanism of action is that by creating an expanded, intravascular lipid phase, equilibria are ...
Oswald Sarah   +3 more
doaj   +5 more sources

Local anesthetic systemic toxicity: current perspectives

open access: yesLocal and Regional Anesthesia, 2018
Kariem El-Boghdadly,1,2 Amit Pawa,1 Ki Jinn Chin3 1Department of Anaesthesia, Guy’s and St Thomas’ NHS Foundation Trust, London, UK; 2School of Medicine, King’s College London, London, UK; 3Department of Anesthesia, Toronto Western ...
El-Boghdadly K, Pawa A, Chin KJ
doaj   +2 more sources

Quinin as a Local Anesthetic. [PDF]

open access: greenJournal of the American Medical Association, 1908
Fredonia, N. Y., Aug. 10, 1908. To the Editor: —Allow me to state that at the annual meeting of the Chautauqua County (N. Y.) Medical Society, held July 14, 1896, I reported that: "Quinin is a safe and efficient anesthetic when used hypodermatically and much safer than cocain." A report of the proceedings of that meeting in the Buffalo Medical ...
V. M. Griswold
openalex   +3 more sources

Acidic Environment Effect on the Push-out Bond Strength of Mineral Trioxide Aggregate Mixed with Different Liquids [PDF]

open access: yesJournal of Dentistry Indonesia, 2015
Mineral trioxide aggregate (MTA) as retrograde filling is always in contact to inflamed tissues in periradicular area. Objective: To investigate the effect of acidic environment on push-out bond strength of MTA mixed with sterile water, local anesthetic,
Diatry Nari Ratih, Asri Riany Putri
doaj   +3 more sources

Heavy gravity combined with light gravity local anesthetic in subarachnoid anesthesia for cesarean section did not reduce the incidence of intraoperative hypotension in maternal women: a prospective cohort study. [PDF]

open access: yesBMC Anesthesiol
Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia.
Qiao W, Liu L, Zhang X, Liu K, Wang L.
europepmc   +2 more sources

Prevention of local anesthetic systemic toxicity

open access: yesJournal of Anaesthesiology Clinical Pharmacology, 2011
There has been a resurgence in the popularity of regional anesthesia in recent years because of the increasing availability of ultrasound guidance. This journal is receiving contributions from authors administering regional anesthesia, with simultaneous ...
Sandhya Yaddanapudi
doaj   +2 more sources

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