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New England Journal of Medicine, 1976
Local anesthetics comprise one of the most widely used classes of drugs in medicine and dentistry, with their remarkable ability to block, quickly and reversibly, the traffic of impulses through both sensory and motor nerves. Historically, the demonstration of the general anesthetic properties of diethyl ether in 1846 antedated by 38 years Koller's ...
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Local anesthetics comprise one of the most widely used classes of drugs in medicine and dentistry, with their remarkable ability to block, quickly and reversibly, the traffic of impulses through both sensory and motor nerves. Historically, the demonstration of the general anesthetic properties of diethyl ether in 1846 antedated by 38 years Koller's ...
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Archives of Dermatology, 1957
Received for publication May 21, 1957. There are a large number of agents that are used for local anesthesia by injection. Most of them I have found have one or more objections. The most commonly used ones are procaine hydrochloride, lidocaine (Xylocaine), and hexylcaine (Cyclaine). All are used in strengths of 1% to 2%.
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Received for publication May 21, 1957. There are a large number of agents that are used for local anesthesia by injection. Most of them I have found have one or more objections. The most commonly used ones are procaine hydrochloride, lidocaine (Xylocaine), and hexylcaine (Cyclaine). All are used in strengths of 1% to 2%.
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THE PHARMACOLOGY OF LOCAL ANESTHETICS
Anesthesiology Clinics of North America, 2000The pharmacology of local anesthetics is an integration of the basic physiology of excitable cells and the mechanism by which local anesthetics are capable of interrupting conduction of neural messages. The common characteristics of the molecules with local anesthetic action have been identified and can explain the properties of the agents.
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Dermatologic Clinics, 1994
Although lidocaine alone will serve as an excellent anesthetic for most patients, using less painful injectable agents, topical anesthetics, and occasionally oral sedation will offer the frightened or pain-intolerant patient an acceptable and effective alternative system of local anesthesia.
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Although lidocaine alone will serve as an excellent anesthetic for most patients, using less painful injectable agents, topical anesthetics, and occasionally oral sedation will offer the frightened or pain-intolerant patient an acceptable and effective alternative system of local anesthesia.
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Local Anesthetics: Eutectic Mixture of Local Anesthetics
1991All commonly available local anesthetics have poor skin penetration when applied topically. One of the main reasons is that a local anesthetic agent needs to be in its cationic form in order to block nerve conduction. But it is the uncharged base which penetrates and diffuses into the tissues after topical administration.
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Potential Therapeutic Application of Local Anesthetics in Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery, 2022Zhaosheng Jin, Hengrui Liu, Jun Lin
exaly
Alkalinization of Local Anesthetics
Regional Anesthesia & Pain Medicine, 1999R, King, M, Hepp, V, Fenton-May
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Effects of local anesthetics on cancer cells
Pharmacology & Therapeutics, 2020Hengrui Liu, James P Dilger, Jun Lin
exaly