Results 11 to 20 of about 5,401,218 (340)

Lipid Emulsion for Local Anesthetic Systemic Toxicity [PDF]

open access: yesAnesthesiology Research and Practice, 2012
The accidental overdose of local anesthetics may prove fatal. The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death.
Sarah Ciechanowicz, Vinod Patil
doaj   +2 more sources

Trial watch: local anesthetics in cancer therapy [PDF]

open access: yesOncoImmunology
Preclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together ...
Killian Carnet Le Provost   +3 more
doaj   +2 more sources

Research advances in the roles of local anesthetics in tumor metastasis and recurrence [PDF]

open access: yesJichu yixue yu linchuang, 2022
Anesthetics are commonly used in the perioperative treatment of tumor. The choice of different anesthetics and anesthesia techniques will affect the proliferation, metastasis, recurrence and prognosis of cancer.
LIU Chang, GUO Xiang-yang
doaj   +1 more source

Direct Cytotoxic and Indirect, Immune-Mediated Effects of Local Anesthetics Against Cancer

open access: yesFrontiers in Oncology, 2022
Local anesthetics are frequently employed during surgery in order to control peri- and postoperative pain. Retrospective studies have revealed an unexpected correlation between increased long-term survival and the use of local anesthetics during ...
Alejandra Wu Chuang   +9 more
doaj   +1 more source

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

open access: yesStem Cell Research & Therapy, 2021
Background A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few studies on the role of local
Xiaoqing Fan   +7 more
doaj   +1 more source

Review of adjuvants to local anesthetics in peripheral nerve blocks: Current and future trends

open access: yesSaudi Journal of Anaesthesia, 2020
In recent anesthetic practice, peripheral nerve blocks (PNBs) are used extensively for surgical anesthesia and nonsurgical analgesia. PNBs offer many benefits over other anesthetic techniques in a certain population of patients, and in some specific ...
G. Krishna Prasad   +2 more
semanticscholar   +1 more source

New patents on topical anesthetics. [PDF]

open access: yes, 2014
Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano   +6 more
core   +1 more source

Chiral Aspects of Local Anesthetics

open access: yesMolecules, 2020
Thanks to the progress made in chemical technology (particularly in the methodologies of stereoselective syntheses and analyses) along with regulatory measures, the number of new chiral drugs registered in the form of pure enantiomers has increased over ...
Ružena Čižmáriková   +4 more
doaj   +1 more source

Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

open access: yesNature Communications, 2020
An on-demand anesthetic that would only take effect when needed and where the intensity of anesthesia could be easily adjustable according to patients’ needs would be highly desirable.
Wei Zhang   +7 more
semanticscholar   +1 more source

Cytotoxicity of Local Anesthetics on Bone, Joint, and Muscle Tissues: A Narrative Review of the Current Literature

open access: yesJournal of Pain Research, 2023
Kaiwen Zhang, Meihong Li, Wenlong Yao, Li Wan Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Li Wan, Department of Anaesthesiology ...
Zhang K, Li M, Yao W, Wan L
doaj  

Home - About - Disclaimer - Privacy