Results 11 to 20 of about 4,888,294 (346)

Trial watch: local anesthetics in cancer therapy [PDF]

OncoImmunology
Preclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together ...
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu   +3 more
doaj   +2 more sources

Evaluation of diagnostic tests for immediate-type allergic reactions to amide group local anesthetics in children. [PDF]

Pediatr Allergy Immunol
Aslan S, Anıl H, Kaya M, Harmancı K.
europepmc   +3 more sources

Research advances in the roles of local anesthetics in tumor metastasis and recurrence [PDF]

Jichu yixue yu linchuang, 2022
Anesthetics are commonly used in the perioperative treatment of tumor. The choice of different anesthetics and anesthesia techniques will affect the proliferation, metastasis, recurrence and prognosis of cancer.
LIU Chang, GUO Xiang-yang
doaj   +1 more source

Direct Cytotoxic and Indirect, Immune-Mediated Effects of Local Anesthetics Against Cancer

Frontiers in Oncology, 2022
Local anesthetics are frequently employed during surgery in order to control peri- and postoperative pain. Retrospective studies have revealed an unexpected correlation between increased long-term survival and the use of local anesthetics during ...
Alejandra Wu Chuang, Alejandra Wu Chuang, Oliver Kepp, Oliver Kepp, Guido Kroemer, Guido Kroemer, Guido Kroemer, Lucillia Bezu, Lucillia Bezu, Lucillia Bezu   +9 more
doaj   +1 more source

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

Stem Cell Research & Therapy, 2021
Background A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few studies on the role of local
Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang, Xueran Chen   +7 more
doaj   +1 more source

Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer [PDF]

Journal of Thoracic Disease, 2016
Hongwei Wang, Leyi Wang, Jiang Li, Suming Tian, Tai-di Zhong, Xiangming Fang   +5 more
openalex   +2 more sources

Local Anesthetics

Pain, 2018
It is generally considered that local anesthetics act directly at the level of the plasma membrane (10, 23, 45). In addition to their anesthetic effects on excitable membranes (4, 45, 50), local anesthetics produce a variety of effects on membranes ...
Carrie Schroeder, Kristopher Schroeder
semanticscholar   +2 more sources

Review of adjuvants to local anesthetics in peripheral nerve blocks: Current and future trends

Saudi Journal of Anaesthesia, 2020
In recent anesthetic practice, peripheral nerve blocks (PNBs) are used extensively for surgical anesthesia and nonsurgical analgesia. PNBs offer many benefits over other anesthetic techniques in a certain population of patients, and in some specific ...
G. Krishna Prasad, S. Khanna, S. Jaishree   +2 more
semanticscholar   +1 more source

Performance of 3 Conversational Generative Artificial Intelligence Models for Computing Maximum Safe Doses of Local Anesthetics: Comparative Analysis. [PDF]

JMIR AI
Suppan M, Fubini PE, Stefani A, Gisselbaek M, Samer CF, Savoldelli GL.   +5 more
europepmc   +2 more sources

Neurotoxicity of local anesthetics in dentistry

Journal of dental anesthesia and pain medicine, 2020
During dental treatment, a dentist usually applies the local anesthesia. Therefore, all dentists should have expertise in local anesthesia and anesthetics. Local anesthetics have a neurotoxic effect at clinically relevant concentrations.
Eun-Jung Kim, H. Kim, Ji-Hye Ahn
semanticscholar   +1 more source