Results 21 to 30 of about 5,862,212 (247)
Revista Brasileira de Anestesiologia, 2008 JUSTIFICATIVA E OBJETIVOS: As microesferas podem ser utilizadas como um sistema de liberação controlada para prolongar a ação de anestésicos locais.
Pedro Paulo Tanaka +6 more
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Molecular and Physicochemical Aspects of Local Anesthetics Acting on Nicotinic Acetylcholine Receptor-containing Membranes [PDF]
, 2002 Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process
Blanton, Michael P., Arias, Hugo Rubén
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Local anesthetics for the Nephrologist [PDF]
Clinical Kidney Journal, 2021 Abstract Several specialists in medicine use local anesthetics. In patients with kidney disease, these agents are used during catheter insertions for hemodialysis and peritoneal dialysis, arteriovenous fistula and graft procedures, kidney transplantation, parathyroidectomy, kidney biopsies, and dental and skin procedures.
Nupur N Uppal +5 more
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Effects of local anesthetics on breast cancer cell viability and migration
BMC Cancer, 2018 Background Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery.
Ru Li +5 more
doaj +1 more source
Influence of local anesthetics upon oxygen radical generation [PDF]
, 1999 P(論文)This study examined whether local anesthetics react with superoxide (O・/2) radicals and generate other oxygen radicals. Lidocaine, mepibacaine, prilocaine, and dibucaine were used as amido type anesthetics ; procaine, and tetracaine as ester type ...
神田, 秀治, 25528
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Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors
Molecules, 2021 Local anesthetics are widely utilized in dentistry, cosmetology, and medicine. Local anesthesia is essential to providing a pain-free experience during dental and local surgeries as well as cosmetic procedures.
John K. Neubert +9 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Progress of Drug Controlled Release Systems for Local Anesthesia
Xiehe Yixue Zazhi, 2022 Reducing the drug administration times and prolonging the postoperative analgesia duration are important requirements of clinical local anesthesia. However, both local anesthetics currently used in the clinic and potentially new anesthetic drugs such as ...
LONG Kai, CAO Pei, JI Tianjiao
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Benzonatate as a local anesthetic
PLOS ONE, 2023 Introduction Benzonatate is an FDA-approved antitussive agent that resembles tetracaine, procaine, and cocaine in its chemical structure. Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will ...
Anna McGuire +4 more
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All local anesthetics bind to the biomembrane by its nitrogen atom in the molecule [PDF]
, 2004 P(論文)The interaction between various local anesthetics and the phospholipid membrane was examined by ^1HNMR (Nuclear Magnetic Resonance) spectroscopy. In order to measure the extent of proximity of various local anesthetics to the membrane, We examinined
26618 +17 more
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