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On controversial issues of systemic toxicity of local anesthetics [PDF]

Вестник анестезиологии и реаниматологии, 2020
The letter draws attention to the provisions on the use of fat emulsion when systemic toxicity of local anesthetics develops that was published in the article titled Disputed Issues of Systemic Toxicity of Local Anesthetics.
R. E. Lakhin
doaj   +2 more sources

Trial watch: local anesthetics in cancer therapy

OncoImmunology
Preclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together ...
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer, Lucillia Bezu   +3 more
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Disputed issues of systemic toxicity of local anesthetics [PDF]

Вестник анестезиологии и реаниматологии, 2020
Objective: assessment of the "systemic toxicity of local anesthetics,” term validity, and a legal appraisal of the term “lipid resuscitation.” Regulatory documents and specialized literature devoted to the terminology of toxicity of local anesthetics ...
V. V. Unzhakov, E. S. Netesin, V. I. Gorbachev   +2 more
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Local anesthetics elicit immune-dependent anticancer effects

Journal for ImmunoTherapy of Cancer, 2022
BACKGROUND: Retrospective clinical trials reported a reduced local relapse rate, as well as improved overall survival after injection of local anesthetics during cancer surgery.
Shuai Zhang, Peng Liu, Wei Xie, Fabrice Barlesi, Guido Kroemer, Oliver Kepp, Juliette Humeau, Jonathan Pol, Liwei Zhao, Lucillia Bezu, Alejandra Wu Chuang, Allan Sauvat, Giulia Cerrato, Julie Le Naour, Peter van Endert   +14 more
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Local Anesthetics In Children [PDF]

, 2022
Continuing Education Activity Local anesthetics (LA) consist of amino amide and amino ester medications used for several medical purposes. This activity will cover the indications, mechanism of action, metabolism, adverse effects, and potential toxicity
McCutchan, Amy, Camfield, Angela S.
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Potential Impact of Local Anesthetics Inducing Granulocyte Arrest and Altering Immune Functions on Perioperative Outcome [PDF]

, 2021
Introduction: Local anesthetics (LAs) are frequently used during anesthesia; however, they may influence granulocyte function which in turn could modify immune responses in the perioperative period. Therefore, the aim of this study was to investigate the
Pfaehler, Sophie-Marie, Wittmann, Sigrid, Bredthauer, Andre, Gruber, Michael, Bitzinger, Diane, Kolle, Gesche, Seyfried, Timo, Metterlein, Thomas, Petermichl, Walter   +8 more
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Cytotoxicity of Local Anesthetics on Bone, Joint, and Muscle Tissues: A Narrative Review of the Current Literature

Journal of Pain Research, 2023
Kaiwen Zhang, Meihong Li, Wenlong Yao, Li Wan Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence: Li Wan, Department of Anaesthesiology ...
Zhang K, Li M, Yao W, Wan L
doaj  

Minimum anesthetic volume in regional anesthesia by using ultrasound-guidance

Revista Brasileira de Anestesiologia, 2016
The ultrasound guidance in regional anesthesia ensures the visualization of needle placement and the spread of Local Anesthetics. Over the past few years there was a substantial interest in determining the Minimum Effective Anesthetic Volume necessary to
Alessandro Di Filippo, Silvia Falsini, Chiara Adembri   +2 more
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Lipid Emulsion for Local Anesthetic Systemic Toxicity

Anesthesiology Research and Practice, 2012
The accidental overdose of local anesthetics may prove fatal. The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death.
Sarah Ciechanowicz, Vinod Patil
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