Results 191 to 200 of about 345,347 (366)

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

open access: yesAdvanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su   +17 more
wiley   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

open access: yesAdvanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Spinal cord anesthesia with meperidine in a patient with hypersensitivity to local anesthesia

open access: yesRevista Cubana de Anestesiología y Reanimación, 2019
Introduction:Meperidine (or pethidine) is a synthetic opioid with well-known local anesthetic properties. It has been safely used intrathecally in general, urological and obstetric surgery.
Alexis Ramón Pineda González
doaj  

Clinical Investigation of Local Anesthetics [PDF]

open access: bronze, 1960
John J. Bonica   +3 more
openalex   +1 more source

ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye

open access: yesAdvanced Science, EarlyView.
A new strategy for constructing smart gel‐based MN patches is developed to overcome the insufficient drug delivery of eye drops to the lacrimal gland. The gel‐based MN patches achieved long‐acting drug release in a ROS‐responsive manner, and separable base in a temperature‐responsive manner.
Jingqing Mu   +10 more
wiley   +1 more source

Impact of local anesthetics on epigenetics in cancer. [PDF]

open access: yesFront Oncol, 2022
Bezu L, Kepp O, Kroemer G.
europepmc   +1 more source

Studies on Local Anesthetics. VI

open access: bronze, 1955
TOZABURO KURIHARA   +2 more
openalex   +2 more sources

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