Local anesthetics - Open Access .click

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Local Anesthetics: Eutectic Mixture of Local Anesthetics

1991
All commonly available local anesthetics have poor skin penetration when applied topically. One of the main reasons is that a local anesthetic agent needs to be in its cationic form in order to block nerve conduction. But it is the uncharged base which penetrates and diffuses into the tissues after topical administration.
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A Superior Local Anesthetic

Archives of Dermatology, 1957
Received for publication May 21, 1957. There are a large number of agents that are used for local anesthesia by injection. Most of them I have found have one or more objections. The most commonly used ones are procaine hydrochloride, lidocaine (Xylocaine), and hexylcaine (Cyclaine). All are used in strengths of 1% to 2%.
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Reactions to Local Anesthetics

JAMA: The Journal of the American Medical Association, 1966
Local anesthetics are used widely by practically all physicians, most of whom are not fully aware of the lethal potential of local anesthetics and the swiftness with which they may precipitate a catastrophe. The perineural concentration of a local anesthetic necessary to interrupt conduction in a nerve fiber is many times greater than that which a ...
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Potential Therapeutic Application of Local Anesthetics in Cancer Treatment

Recent Patents on Anti-Cancer Drug Discovery, 2022
Zhaosheng Jin, Hengrui Liu, Yongjian Lin +2 more
exaly

LOCAL ANESTHETICS