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Benzonatate as a local anesthetic
PLOS ONE, 2023 Introduction Benzonatate is an FDA-approved antitussive agent that resembles tetracaine, procaine, and cocaine in its chemical structure. Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will ...
Anna McGuire +4 more
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Chiral Aspects of Local Anesthetics
Molecules, 2020 Thanks to the progress made in chemical technology (particularly in the methodologies of stereoselective syntheses and analyses) along with regulatory measures, the number of new chiral drugs registered in the form of pure enantiomers has increased over ...
Ružena Čižmáriková +4 more
doaj +1 more source
The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
arxiv +1 more source
Brachial Plexus Nerve Trunk Segmentation Using Deep Learning: A Comparative Study with Doctors' Manual Segmentation [PDF]
[J]. Ultrasound in Medicine & Biology, 2024, 50(3): 374-383, 2022 Ultrasound-guided nerve block anesthesia (UGNB) is a high-tech visual nerve block anesthesia method that can observe the target nerve and its surrounding structures, the puncture needle's advancement, and local anesthetics spread in real-time. The key in UGNB is nerve identification.
arxiv +1 more source
Lipid Emulsion for Local Anesthetic Systemic Toxicity
Anesthesiology Research and Practice, 2012 The accidental overdose of local anesthetics may prove fatal. The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death.
Sarah Ciechanowicz, Vinod Patil
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Revista Brasileira de Anestesiologia, 2008 JUSTIFICATIVA E OBJETIVOS: As microesferas podem ser utilizadas como um sistema de liberação controlada para prolongar a ação de anestésicos locais.
Pedro Paulo Tanaka +6 more
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On controversial issues of systemic toxicity of local anesthetics
Вестник анестезиологии и реаниматологии, 2020 The letter draws attention to the provisions on the use of fat emulsion when systemic toxicity of local anesthetics develops that was published in the article titled Disputed Issues of Systemic Toxicity of Local Anesthetics.
R. E. Lakhin
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Adjuvants to local anesthetics: Current understanding and future trends
World Journal of Clinical Cases, 2017 Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system.
A. Swain +3 more
semanticscholar +1 more source