Results 201 to 210 of about 33,533 (255)

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Oral step-down vs full-course intravenous antibiotic therapy for infective endocarditis: Protocol for a systematic review and meta-analysis. [PDF]

PLoS One
Cruz-Cuevas JD, Amador Bedoya JA, Méndez Gaitán MP, Ramírez MC, González Quiroga J, Rodríguez Villegas A, Sanín Reyes A.   +6 more
europepmc   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

Comorbidities, medication use, and overall survival in eight cancers: a multinational cohort study of 1.7 million patients across Europe. [PDF]

Lancet Reg Health Eur
López-Sánchez I, Palomar-Cros A, Claire R, Pérez-Crespo L, Giuliodori A, Koblbauer I, Dietz J, Elvidge J, Koh J, Golozar A, Ramirez-Anguita JM, Leis A, Mayer MA, Symmers N, Vallet M, McLean C, Hall PS, Mosseveld M, Verhamme K, Enerly E, Prinsen P, Evers J, Oja M, Kolde R, Marcos-Gragera R, Fey E, Porkka K, Taveira-Gomes T, Estevinho F, Conde AM, Conde JM, Sanchez CM, Fournier E, Pistillo A, Chen X, Corby G, Robinson A, Sanchez-Santos MT, Delmestri A, Man WY, Català M, Alcalde-Herraiz M, Burn E, Prieto-Alhambra D, Duarte-Salles T, Newby D.   +45 more
europepmc   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Comprehensive Review of Hydrogel-Mediated Strategies for Diabetic Wound Healing. [PDF]

Int J Mol Sci
Fan Z, Li J, Zhong C, Liu D, Fan H, Jiang L, Wang G.   +6 more
europepmc   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Research progress on self-assembled supramolecular bioactive materials from herbal natural products and their applications in anti-infection field. [PDF]

Mater Today Bio
Xue H, Yu H, Zhao P, Cheng S, Wang C, Tan J.   +5 more
europepmc   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

<i>Brucella</i> Infection Associated with Abdominal Aortic Rupture and Retroperitoneal Hematoma: A Case Report. [PDF]

J Inflamm Res
Shao T, Chen N, Sun Q, Sheng P.
europepmc   +1 more source