Results 31 to 40 of about 33,717 (257)

DIABETIC FOOT SYNDROME: IMPORTANCE OF MICROBIOLOGICAL MONITORING AND ANTIMICROBIAL PENETRATION OF CHEMOTHERAPEUTIC AGENTS INTO THE SOFT TISSUE LOWER LIMB IN DETERMINING THE TREATMENT [PDF]

Research Results in Pharmacology, 2016
Foot infections are a common and serious problem in persons with diabetes. Persistent ulcers in patients with diabetic foot syndrome in 85% of cases lead to amputation because of secondary infection and growing gangrene that significantly worsen the ...
Tatyana Malorodova, Tatyana Pokrovskaya, Elena Kazakova, Zhanna Urozhevskaya   +3 more
doaj   +3 more sources

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Bisphosphonate-Functionalized Imaging Agents, Anti-Tumor Agents and Nanocarriers for Treatment of Bone Cancer. [PDF]

, 2017
Item does not contain fulltextBone metastases result from the invasion of primary tumors to bone. Current treatment modalities include local treatments such as surgery and radiotherapy, while systemic treatments include chemotherapy and (palliative ...
Boerman, O.C., Leeuwenburgh, S.C.G., Margiotta, N., Beucken, J.J.J.P van den, Iafisco, M., Nadar, A.   +5 more
core   +3 more sources

Incidência de infecção do sítio cirúrgico com o preparo pré-operatório utilizando iodopolividona 10% hidroalcoólica e clorexidina alcoólica 0,5%

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: analisar a incidência de infecção do sítio cirúrgico, quando o preparo pré-operatório da pele foi realizado com iodopolividona 10% em solução hidroalcoólica e clorexidina 0,5% alcoólica, MÉTODOS: estudo longitudinal randomizado, a partir de ...
Ana Luzia Rodrigues, Maria de Lourdes Pessole Biondo Simões   +1 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Advances in Dendrimer-Based Anti-Infective Systems: In Vivo Insights and Perspectives

Pharmaceutics
The rise of antimicrobial resistance and the persistence of difficult-to-treat infections have stimulated interest in new strategies to overcome these problems.
Charlotte Aparici, Kevin Antraygues, Vania Bernardes-Génisson, Manuel S. Rodriguez, Cédric-Olivier Turrin, Valérie Maraval, Anne-Marie Caminade   +6 more
doaj   +1 more source

Susceptibility of some oral microorganisms to chlorhexidine and paramonochlorophenol Susceptibilidade de alguns microrganismos orais frente à clorexidina e ao paramonoclorofenol

Brazilian Oral Research, 2004
Since the use of antimicrobial agents is required in endodontic therapies, this study aimed at determining the minimum inhibitory concentrations (MICs) of chlorhexidine digluconate and paramonochlorophenol (PMC) against microorganisms commonly found in ...
Crystiane Venditi Gomes do Amorim, Carlos Eduardo Aun, Marcia Pinto Alves Mayer   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source