Results 211 to 220 of about 6,711,395 (246)

Global Evolution of Microbiological Patterns and Pharmacological Guidance in the Management of Peritoneal Dialysis-Associated Peritonitis: An Evolution of Epidemiology and Clinical Practice. [PDF]

Pathogens
Suliman O, Wu HHL, Lewis D, Kalra PA, Chinnadurai R.   +4 more
europepmc   +1 more source

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Early Outcomes After Discontinuing Routine Gentamicin Irrigation During AMS 800 Artificial Urinary Sphincter Implantation: A Single-Centre Retrospective Before-After Cohort Study. [PDF]

Antibiotics (Basel)
Skrzypczyk MA, Pliszka A, Białek Ł, Rydzińska M, Karoń W, Dobruch J, Lemiński A.   +6 more
europepmc   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Early-onset neonatal sepsis and neonatal antibiotic exposure in Hungary a nationwide population-based study. [PDF]

Eur J Pediatr
Mari J, Klingenberg C, Rosa-Mangeret F, Mlinarics LS, Szabó M, Valek A, Kiss JK, Tálosi G.   +7 more
europepmc   +1 more source

Antibiotic Management Following Urine and Blood Culture Results: A Retrospective Single-Centre Observational Study at University Hospital Hairmyres, United Kingdom. [PDF]

Cureus
Ibrahim YY.
europepmc   +1 more source

A National Collaborative Project to Decrease Healthcare-Associated Infections in Intensive Care Units: Results from Stop Hospital Infection, in Portugal. [PDF]

Antibiotics (Basel)
Malheiro R, Gomes AA, Nunes C, Sousa P, Borem P, Paiva JA, Lebre A.   +6 more
europepmc   +1 more source

Economic Barriers to Antimicrobial Susceptibility Testing as a Structural Contributor to Antimicrobial Resistance in Low- and Middle-Income Countries: A Narrative Review. [PDF]

Infect Drug Resist
Abdi YH, Bashir SG, Ali SM.
europepmc   +1 more source