Results 91 to 100 of about 334,763 (303)

Exploring strategic turnaround in English Local Authorities

, 2013
This thesis explores the nature of strategic turnaround in English local authorities during the period of Comprehensive Performance Assessment (CPA) between 2002 and 2008.
Jones, M
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Debt is not a dirty word: the role and use of debt in local government [PDF]

, 2014
This research suggests the sensible use of debt by local councils can address infrastructure backlogs and positively support sustainable local communities and organisation performance.
John Comrie
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Partnerships with Local Authorities and Health Agencies

, 2010
A report of research carried out by the Policy Research Institute, Leeds Metropolitan University on behalf of the Department for Work and Pensions (DWP Research Report 693).
Purcell, Martin, Hawtin, Murray, Clarke, James, Department for Work & Pensions, Wymer, Penny, Percy-Smith, Janie, Jassi, Sukky   +6 more
core  

The impact of management control systems on performance of Malaysian local authorities [PDF]

, 2015
An increasing number of profit and non-profit organizations implementing management control systems (MCSs) have proven the importance of the systems in improving organizational performance.
Mohamed, Nafsiah, Ilias, Norazlina, Abdulatiff, Nik Kamaruzaman   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Budgetary Dynamics in The Local Authorities in Israel

This study examines the short-run effects and dynamics of exogenous shocks to the regular budgets of the local authorities in Israel with emphasis on the reduction in government participation and taking into account the heterogeneity of the local ...
Navon, Guy
core  

National Evaluation of the Capacity Building Programme in English Local Government: Annex 4: Follow On Study of Progress in Seven Case Study Improvement Partnerships

, 2008
This report is one of a series of outputs from the national evaluation of the Capacity Building Programme for local government in England (CBP), being undertaken by a team of researchers at the Policy Research Institute (PRI) at Leeds Metropolitan ...
Stevens, A, Kelsey, S, Dowson, L, Halliday, S, Nunn, A, Purcell, M   +5 more
core  

CONCEPTUALIZATION OF FINANCIAL RESOURCES OF LOCAL AUTHORITIES

Baltic Journal of Economic Studies, 2016
Aim of the article is to study and generalize scientific approaches to the determination of essence, content and components of financial resources of local authorities.
Аnna Briazkalo
doaj