Results 151 to 160 of about 2,111,359 (357)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A local-authority specific definition of research: Results from a Delphi study. [PDF]

Public Health Pract (Oxf)
Brown LM, Sowden S, Briggs ADM, Dennington-Price A, Dutta V, Hampshaw S, Humphreys E, Johns T, Levitas A, Murphy R, Needham K, Renwick L, Hayes L.   +12 more
europepmc   +1 more source

A systems approach to the exploration of research activity and relationships within a local authority. [PDF]

Health Res Policy Syst, 2021
Fynn JF, Jones J, Jones A.
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Conducting school-based health surveys with secondary schools in England: advice and recommendations from school staff, local authority professionals, and wider key stakeholders, a qualitative study. [PDF]

BMC Med Res Methodol, 2023
Hatch LM, Widnall EC, Albers PN, Hopkins GL, Kidger J, de Vocht F, Kaner E, van Sluijs EMF, Fairbrother H, Jago R, Campbell RM.   +10 more
europepmc   +1 more source

Supplier guidance note 1 : local authority [PDF]

, 2013

core  

Decentralizing the provision of health services : an incomplete contracts approach [PDF]

The author studies the allocation-between a central government and a local authority--of responsibility for planning, financing, and operations for the delivery of health services, in the context of an incomplete contracts model.
Jack, William
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Factors supporting research capacity development in an English local authority: a qualitative description and comparison with proposed mechanisms. [PDF]

Health Res Policy Syst
Kennedy SM, Haywood A, Hampshaw S, Cooke J.   +3 more
europepmc   +1 more source

Outstanding local authority children’s services 2009 [PDF]

, 2010

core