Results 21 to 30 of about 169,388 (257)

Local sheep breeds from peninsular Southern Italy: breeding and demography

open access: yesItalian Journal of Animal Science, 2007
In the context of a Special Project financed by the MIPAF, facing the exploitation of the autochthonous ovine breeds from peninsular Southern Italy, an investigation has been carried out on the Altamurana, Bagnolese, Laticauda, Leccese and Gentile di Puglia breeds.
CECCHI, FRANCESCA   +5 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On the Breeds of Cattle—Historic and Current Classifications [PDF]

open access: yes, 2011
Classification of cattle breeds contributes to our understanding of the history of cattle and is essential for an effective conservation of genetic diversity.
Adametz   +92 more
core   +2 more sources

Crossed beaks in a local Swiss chicken breed [PDF]

open access: yesBMC Veterinary Research, 2018
Crossed beaks have been reported to occur in Appenzeller Barthuhn, a local Swiss chicken breed. The assumed causes for this beak deformity which are also seen in other bird species including domestic chickens, range from environmental influences to genetic factors.
Sara Joller   +7 more
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Implementation of Breed-Specific Traits for a Local Sheep Breed

open access: yesAgricultural Sciences, 2018
In recent decades, a considerable number of local breeds have been replaced by high-yielding breeds for reasons of profitability. Many local breeds are now threatened by extinction and the loss of their native genetic diversity. The need to conserve breeds and their genetic diversity has a major importance due to the necessity for genetic change within
Jonas Schäler   +2 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Livestock breeds and Organic farming systems [PDF]

open access: yes, 2007
Organic livestock farming has grown in Wales in recent years. It is focused on producing animals from a predominantly forage-based system, with an emphasis on maintaining animal health through improved welfare and a reduction in the use of routine ...
Frost, David   +2 more
core  

Italian local goat breeds have better milk coagulation properties than cosmopolitan breed [PDF]

open access: yesItalian Journal of Animal Science, 2020
Native goat breeds play an important role both in the safeguarding of biodiversity and the development of local economy. This study aimed to evaluate milk coagulation properties (MCP) of local (Garganica, Girgentana, Maltese, Mediterranean Red) and cosmopolitan (Saanen) goat breeds.
Sarah Currò   +6 more
openaire   +7 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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